Table 3 Results of multivariate binary logistic regression analysis of bone markers

Local response (no local response)

OR

95 % CI (OR)

p-value

 Arm (A – reference)

0.033

0.004 – 0.311

0.003

 PYD

1.000

0.992 – 1.008

0.986

 DPD

1.023

0.974 – 1.074

0.371

 CTX-I

10.550

0.003 – >100

0.569

 BAP

1.011

0.996 – 1.025

0.142

 NTX

0.870

0.688 – 1.101

0.245

 PINP

0.968

0.938 – 0.999

0.043

Prevention of SRE (SRE = 0)

OR

95 % CI (OR)

p-value

 Arm (A – reference)

3.302

0.877 – 12.431

0.077

 PYD

0.998

0.994 – 1.002

0.373

 DPD

1.006

0.982 – 1.031

0.633

 CTX-I

0.323

0.001 – 81.336

0.689

 BAP

0.974

0.950 – 0.998

0.034

 NTX

0.988

0.861 – 1.134

0.865

 PINP

1.025

1.001 – 1.049

0.044

Solitary metastasis (n = 1)

OR

95 % CI (OR)

p-value

 Arm (A – reference)

1.692

0.477 – 6.007

0.416

 PYD

1.001

0.997 – 1.005

0.512

 DPD

1.004

0.980 – 1.029

0.761

 CTX-I

0.359

0.001 – >100

0.723

 BAP

0.997

0.985 – 1.009

0.592

 NTX

1.083

0.939 – 1.249

0.275

 PINP

0.998

0.981 – 1.016

0.829