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Fig. 5 | BMC Cancer

Fig. 5

From: RETRACTED ARTICLE: CDK4 and miR-15a comprise an abnormal automodulatory feedback loop stimulating the pathogenesis and inducing chemotherapy resistance in nasopharyngeal carcinoma

Fig. 5

miR-15a suppressed cell cycle progression and cell growth in NPC. a and b. miR-15a mimics inhibited cell proliferation in NPC 5-8F and HONE1 cells by MTT assay. c and d. miR-15a mimics blocked cell cycle progression from G1 to S phase in NPC 5-8F and HONE1 cells. e. Lentivirus-mediated expression of miR-15a suppressed tumorigenesis of NPC 5-8F and HONE1 cells in vivo in nude mice. f and g. miR-15a inhibitor partially restored cell proliferation in CDK4-suppressed NPC cells. (*P < 0.05)

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BMC Cancer

ISSN: 1471-2407

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