Table 2 GeneGO Process Networks significantly enriched for both up- and down-regulated genes in MCF-7-Snail vs MCF-7-Control cells (FDR = 0.03104). P/T – differentially expressed genes mapped to a given map/total number of genes in a map
# | Network | p-value | FDR | P/T |
|---|---|---|---|---|
1 | Signal transduction_WNT signaling | 1.774E-07 | 2.622E-05 | 100/170 |
2 | Cell adhesion_Cell junctions | 3.278E-07 | 2.622E-05 | 89/149 |
3 | Cytoskeleton_Regulation of cytoskeleton rearrangement | 5.064E-07 | 2.701E-05 | 104/181 |
4 | Cell adhesion_Cadherins | 1.194E-06 | 4.777E-05 | 100/175 |
5 | Cytoskeleton_Actin filaments | 3.552E-06 | 1.137E-04 | 99/176 |
6 | Development_Hedgehog signaling | 1.016E-05 | 2.598E-04 | 129/244 |
7 | Reproduction_FSH-beta signaling pathway | 1.136E-05 | 2.598E-04 | 86/152 |
8 | Development_Neurogenesis_Axonal guidance | 4.544E-05 | 9.088E-04 | 115/219 |
9 | Signal transduction_Androgen receptor nuclear signaling | 5.687E-05 | 9.838E-04 | 70/123 |
10 | Development_Regulation of angiogenesis | 6.148E-05 | 9.838E-04 | 109/207 |
11 | Cell adhesion_Attractive and repulsive receptors | 1.134E-04 | 1.649E-03 | 91/170 |
12 | Development_Neurogenesis_Synaptogenesis | 6.650E-04 | 7.983E-03 | 92/179 |
13 | Cell cycle_G1-S Growth factor regulation | 6.820E-04 | 7.983E-03 | 96/188 |
14 | Development_Ossification and bone remodeling | 7.539E-04 | 7.983E-03 | 80/153 |
15 | Signal transduction_ESR1-nuclear pathway | 8.718E-04 | 7.983E-03 | 104/207 |
16 | Development_EMT_Regulation of epithelial-to-mesenchymal transition | 8.718E-04 | 7.983E-03 | 104/207 |
17 | Signal Transduction_Cholecystokinin signaling | 8.781E-04 | 7.983E-03 | 52/93 |
18 | Signal transduction_ERBB-family signaling | 8.981E-04 | 7.983E-03 | 40/68 |
19 | Muscle contraction_Relaxin signaling | 2.135E-03 | 1.798E-02 | 37/64 |
20 | Apoptosis_Endoplasmic reticulum stress pathway | 2.366E-03 | 1.819E-02 | 44/79 |
21 | Development_Neurogenesis in general | 2.387E-03 | 1.819E-02 | 93/187 |
22 | Neurophysiological process_Circadian rhythm | 2.520E-03 | 1.833E-02 | 30/50 |
23 | Cardiac development_FGF_ErbB signaling | 2.858E-03 | 1.988E-02 | 64/123 |
24 | Cardiac development_Wnt_beta-catenin, Notch, VEGF, IP3 and integrin signaling | 3.396E-03 | 2.181E-02 | 70/137 |
25 | Signal transduction_ESR1-membrane pathway | 3.425E-03 | 2.181E-02 | 43/78 |
26 | Cardiac development_Role of NADPH oxidase and ROS | 3.669E-03 | 2.181E-02 | 64/124 |
27 | Reproduction_Gonadotropin regulation | 3.680E-03 | 2.181E-02 | 81/162 |
28 | Signal transduction_NOTCH signaling | 4.606E-03 | 2.629E-02 | 109/227 |
29 | Signal transduction_Androgen receptor signaling cross-talk | 4.766E-03 | 2.629E-02 | 35/62 |
30 | Reproduction_Male sex differentiation | 5.820E-03 | 3.104E-02 | 111/233 |