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Table 2 Protein expression for SFKs and downstream markers of activation and disease specific survival (n = 192)

From: Nuclear expression of Lyn, a Src family kinase member, is associated with poor prognosis in renal cancer patients

Protein Median (IQRa) p-value
Src Kinase   
  Membrane 50 (27–80) 0.237
  Cytoplasmic 37 (27–68) 0.132
  Nucleus 2 (0–12) 0.726
SFK (Y416)   
  Membrane 5 (0–13) 0.206
  Cytoplasmic 7 (0–20) 0.868
  Nucleus 2 (0–11) 0.735
FAK (Y861)   
  Membrane 13 (3–37) 0.008
  Cytoplasmic 7 (0–20) 0.546
  Nuclear 60 (43–77) 0.532
FAK (Y397)   
  Membrane 93 (41–147) 0.001
  Cytoplasmic 77 (33–133) 0.252
  Nuclear 152 (127–180) 0.846
Paxillin   
  Membrane 3 (0–10) 0.050
  Cytoplasmic 7 (0–10) 0.335
  Nuclear 3 (0–63) 0.031
FYN   
  Membrane 15 (2–30) 0.006
  Cytoplasmic 8 (2–17) 0.393
  Nuclear 13 (0–109) 0.139
LYN   
  Membrane 37 (10–77) 0.141
  Cytoplasmic 70 (38–202) 0.446
  Nuclear 13 (0–109) 0.019
FGR   
  Membrane 7 (0–22) 0.087
  Cytoplasmic 33 (15–60) 0.252
  Nuclear 9 (3–27) 0.503
HCK   
  Membrane 63 (27–103) 0.038
  Cytoplasmic 47 (30–27) 0.109
  Nuclear 57 (30–80) 0.197
YES   
  Membrane 47 (17–70) 0.0004
  Cytoplasm 38 (23–69) 0.271
  Nucleus 43 (27–62) 0.842
  1. aIQR = interquartile range
  2. P-values in bold are greater than the significance threshold of 0.05