Table 2 Associations between hypermethylated and hypomethylated CpG sites and clinicopathological features
From: GFRA3 promoter methylation may be associated with decreased postoperative survival in gastric cancer
Post-op survival | Lymph node metastasis | Tumor size | Lauren classification | Metaplasia | Atrophy | H. pylori | |
|---|---|---|---|---|---|---|---|
CpgID/Gene promoter Hypermethylated in the tumor | |||||||
cg09350274/GFRA3 | r = −0.69 p = 0.002 | r = 0.52 p = 0.028 | r = 0.48 p = 0.42 | r = 0.480 p = 0.044 | r = −0.590 p = 0.01 | ||
cg02720618/ESR1 | r = 0.56 p = 0.016 | ||||||
cg04623837/HCG9 | r = 0.64 p = 0.004 | ||||||
cg07307078/TUBB6 | r = 0.49 p = 0.04 | ||||||
cg08615333/TGFB3 | r = 0.5 p = 0.037 | r = 0.504 p = 0.033 | |||||
cg01566170/CAPN2 | r = −0.53 p = 0.023 | r = 0.526 p = 0.025 | |||||
cg16986846/SCGB2A1 | r = −0.576 p = 0.012 | ||||||
cg02633817/FXYD3 | r = −0.474 p = 0.047 | ||||||
cg20640433/LAMA2 | r = 524 p = 0.026 | ||||||
cg21905630/GSH2 | r = 0.52 p = 0.028 | ||||||
cg13718960/RNASE1 | r = 0.554 p = 0.017 | ||||||
cg19118812/ELMO1 | r = −0.546 p = 0.019 | ||||||
cg26557658/FAM43B | r = −0.604 p = 0.008 | ||||||
cg03616357/FLJ21159 | r = 0.574 p = 0.013 | ||||||
cg08615333/TGFB3 | r = 0.504 p = 0.033 | ||||||
cg14189571/ZFP42 | r = 0.484 p = 0.042 | ||||||
cg17872757/FLI1 | r = 0.495 p = 0.037 | ||||||
cg21790626/ZNF154 | r = 0.573 p = 0.013 | ||||||
cg27546237/COL4A1 | r = 0.527 p = 0.025 | ||||||
CpgID/Gene promoter Hypomethylated in the tumor | |||||||
cg13694749/SCN4A | r = −0.638 p = 0.004 | ||||||
cg18059088/HS3ST1 | r = −0.474 p = 0.047 | ||||||
cg26619317/CNN3 | r = 0.481 p = 0.043 | ||||||
cg07131544/NCR2 | r = 0.496 p = 0.036 | ||||||
cg14696870/FCER1A | r = −0.567 p = 0.014 | ||||||
cg20676475/LCE3D | r = −0.708 p = 0.001 | ||||||
cg00974864/FCGR3B | r = −562 p = 0.015 | ||||||
cg13180098/RHO | r = −0.604 p = 0.008 | r = −0.597 p = 0.009 | r = 0.682 p = 0.002 | ||||
cg24691453/S100A4 | r = 0.470 p = 0.49 | ||||||
cg15309006/LOC63928 | r = −0.499 p = 0.035 | ||||||
cg26789453/TMEM116 | r = −0.512 p = 0.030 | ||||||
cg26264314/NALP5 | r = −0.474 p = 0.047 | ||||||
cg20383064/BFSP2 | r = −0.487 p = 0.040 | ||||||
cg25119415/MNDA | r = −0.646 p = 0.004 | r = −0.514 p = 0.029 | r = 0.547 p = 0.019 | ||||
cg14603345/BTBD3 | p = −0.483 r = 0.042 | ||||||
cg17356733/IFNGR2 | r = −0.480 p = 0.044 | ||||||
cg23756272/BCL2 | r = −0.500 p = 0.035 | ||||||
cg00842351/TJP2 | r = −527 p = 0.24 | ||||||
cg25248094/SH2D1A | r = 0.487 p = 0.041 | r = −0.526 p = 0.025 | |||||
cg04454050/TREML1 | 0.474 0.047 | ||||||
cg02611419/KCNK17 | r = −502 p = 0.034 | ||||||
cg05252264/FCAR | r = 0.587 p = 0.10 | ||||||
cg22268164/TRHR | r = −0.619 p = 0.006 | ||||||
cg02046017/LOC220070 | r = 0.475 p = 0.046 | ||||||
cg09191232/PAPSS1 | r = −0.581 p = 0.011 |