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Table 6 Classifier for thyroid neoplasm subtyping based on the combinatorial patterns of miRNA expression changes, and its diagnostic characteristics

From: miRNA profiling, detection of BRAF V600E mutation and RET-PTC1 translocation in patients from Novosibirsk oblast (Russia) with different types of thyroid tumors

Histology-based tumor type Components of the miRNA pattern Criterion Specificity (%) Sensitivity (%) PPV (%) NPV (%)
PTC
(n = 108)
miR-21, −221, −222, −205, −146b, −31, −187, −181b, −375 Levels of miR-146b or −31 are increased, alternatively levels of at least 3 out of the remaining miRNAs are increased/level of miR-31 is not reduced 98.00 92.59 98.04 92.45
MTC (n = 4) miR-21, −221, −222, −187, −375, −205, −31, −199b, −144, miR-146b level are not increased
At least two miRNAs out of miR-21,- 221, −222, −187, −375 are above norm
at least 3 miRNas out of miR-205, −31, −199b, −144 display reduced expression
99.51 75.00 75.0 99.51
FTC (n = 16) miR-221, −222, −187, −205, −31, −199b, −144, −375 Expression levels of miR-21, 146b, 205, 375 are not increased
Expression levels of miR-221 or −222 or −187 are increased
Expression level of miR-199b is reduced
Of miR-205, −31, −144, −375, at least one miRNA shows reduced expression
99.48 81.25 92.86 98.45
FA (n = 41) miR-205, −200a, −200b, −31, −199b, −144 -375 Expression levels of miR-21, −221, −222, −200b are not increased
Of miR-181b, −187, −375 one species at most shows increased expression
Of miR-205, −200а, −200b, −31, −199b, −144, −375 levels of at least two miRNAs is reduced
86.83 65.85 55.10 91.19
Thyroid cancer (without subtyping)
(n = 124)
miR-21, −221, −222, −205, −146b, −31, −187, −181b, −375 Expression levels of miR-21, −146b, −221 or −31 are increased, alternatively any two species out of miR-222, −205, −181b, −187, −375 show increased expression levels 96.59 90.83 97.32 88.54