Table 6 Classifier for thyroid neoplasm subtyping based on the combinatorial patterns of miRNA expression changes, and its diagnostic characteristics

PTC

(n = 108)

miR-21, −221, −222, −205, −146b, −31, −187, −181b, −375

Levels of miR-146b or −31 are increased, alternatively levels of at least 3 out of the remaining miRNAs are increased/level of miR-31 is not reduced

MTC (n = 4)

miR-21, −221, −222, −187, −375, −205, −31, −199b, −144,

miR-146b level are not increased

At least two miRNAs out of miR-21,- 221, −222, −187, −375 are above norm

at least 3 miRNas out of miR-205, −31, −199b, −144 display reduced expression

FTC (n = 16)

miR-221, −222, −187, −205, −31, −199b, −144, −375

Expression levels of miR-21, 146b, 205, 375 are not increased

Expression levels of miR-221 or −222 or −187 are increased

Expression level of miR-199b is reduced

Of miR-205, −31, −144, −375, at least one miRNA shows reduced expression

FA (n = 41)

miR-205, −200a, −200b, −31, −199b, −144 -375

Expression levels of miR-21, −221, −222, −200b are not increased

Of miR-181b, −187, −375 one species at most shows increased expression

Of miR-205, −200а, −200b, −31, −199b, −144, −375 levels of at least two miRNAs is reduced

Thyroid cancer (without subtyping)

(n = 124)

miR-21, −221, −222, −205, −146b, −31, −187, −181b, −375

Expression levels of miR-21, −146b, −221 or −31 are increased, alternatively any two species out of miR-222, −205, −181b, −187, −375 show increased expression levels