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Table 5 Diagnostic characteristics of relative miRNA expression levels as applied to thyroid cancer subtyping

From: miRNA profiling, detection of BRAF V600E mutation and RET-PTC1 translocation in patients from Novosibirsk oblast (Russia) with different types of thyroid tumors

Cancer type miRNA Expression level Specificity (%) Sensitivity (%) PPV (%) NPV (%)
PTC
(n = 108)
21 Up 99.00 37.96 97.62 59.64
221 Up 83.00 81.48 83.81 80.58
222 Up 92.00 75.93 91.11 77.97
205 Up 98.99 26.85 96.67 55.37
146b Up 100.00 88.89 100.00 89.29
181b Up 95.00 27.78 85.71 54.91
31 Up 100.00 48.45 100.00 65.28
187 Up 90.00 50.00 84.38 62.50
375 Up 94.90 49.06 91.23 63.27
MTC (n = 4) 21 Up 79.90 25.00 2.38 98.19
221 Up 50.00 75.00 2.86 99.03
222 Up 57.35 75.00 3.33 99.15
205 Up 83.25 75.00 8.11 99.41
31 Down 84.49 75.00 9.38 99.37
187 Up 69.12 25.00 1.56 97.92
199b Down 47.06 100.00 2.70 100.00
144 Down 74.51 100.00 5.45 100.00
375 Up 72.64 66.67 3.51 99.32
FTC (n = 16) 221 Up 51.04 68.75 10.48 95.15
222 Up 55.21 25.00 4.44 89.83
205 Down 86.39 68.75 29.73 97.06
31 Down 86.36 53.33 25.00 95.60
187 Up 68.75 25.00 6.25 91.67
199b Down 49.74 93.75 13.51 98.96
FA (n = 41) 205 Down 83.23 22.50 24.32 81.76
200a Down 90.97 37.84 50.00 85.98
31 Down 86.36 29.73 34.38 83.65
199b Down 51.20 73.17 27.03 88.54
144 Down 73.49 26.83 20.00 80.26
200b Down 87.95 34.15 41.18 84.39
Goiter (n = 39) 200a Down 87.10 21.62 28.57 82.32
31 Down 84.31 21.05 25.00 81.13
199b Down 46.43 53.85 18.92 81.25
144 Down 75.60 35.90 25.45 83.55
192 Down 95.24 20.00 50.00 83.33
200b Down 86.31 28.21 32.35 83.82
  1. PPV positive predictive value, NPV negative predictive value