Table 5 Diagnostic characteristics of relative miRNA expression levels as applied to thyroid cancer subtyping
Cancer type | miRNA | Expression level | Specificity (%) | Sensitivity (%) | PPV (%) | NPV (%) |
|---|---|---|---|---|---|---|
PTC (n = 108) | 21 | Up | 99.00 | 37.96 | 97.62 | 59.64 |
221 | Up | 83.00 | 81.48 | 83.81 | 80.58 | |
222 | Up | 92.00 | 75.93 | 91.11 | 77.97 | |
205 | Up | 98.99 | 26.85 | 96.67 | 55.37 | |
146b | Up | 100.00 | 88.89 | 100.00 | 89.29 | |
181b | Up | 95.00 | 27.78 | 85.71 | 54.91 | |
31 | Up | 100.00 | 48.45 | 100.00 | 65.28 | |
187 | Up | 90.00 | 50.00 | 84.38 | 62.50 | |
375 | Up | 94.90 | 49.06 | 91.23 | 63.27 | |
MTC (n = 4) | 21 | Up | 79.90 | 25.00 | 2.38 | 98.19 |
221 | Up | 50.00 | 75.00 | 2.86 | 99.03 | |
222 | Up | 57.35 | 75.00 | 3.33 | 99.15 | |
205 | Up | 83.25 | 75.00 | 8.11 | 99.41 | |
31 | Down | 84.49 | 75.00 | 9.38 | 99.37 | |
187 | Up | 69.12 | 25.00 | 1.56 | 97.92 | |
199b | Down | 47.06 | 100.00 | 2.70 | 100.00 | |
144 | Down | 74.51 | 100.00 | 5.45 | 100.00 | |
375 | Up | 72.64 | 66.67 | 3.51 | 99.32 | |
FTC (n = 16) | 221 | Up | 51.04 | 68.75 | 10.48 | 95.15 |
222 | Up | 55.21 | 25.00 | 4.44 | 89.83 | |
205 | Down | 86.39 | 68.75 | 29.73 | 97.06 | |
31 | Down | 86.36 | 53.33 | 25.00 | 95.60 | |
187 | Up | 68.75 | 25.00 | 6.25 | 91.67 | |
199b | Down | 49.74 | 93.75 | 13.51 | 98.96 | |
FA (n = 41) | 205 | Down | 83.23 | 22.50 | 24.32 | 81.76 |
200a | Down | 90.97 | 37.84 | 50.00 | 85.98 | |
31 | Down | 86.36 | 29.73 | 34.38 | 83.65 | |
199b | Down | 51.20 | 73.17 | 27.03 | 88.54 | |
144 | Down | 73.49 | 26.83 | 20.00 | 80.26 | |
200b | Down | 87.95 | 34.15 | 41.18 | 84.39 | |
Goiter (n = 39) | 200a | Down | 87.10 | 21.62 | 28.57 | 82.32 |
31 | Down | 84.31 | 21.05 | 25.00 | 81.13 | |
199b | Down | 46.43 | 53.85 | 18.92 | 81.25 | |
144 | Down | 75.60 | 35.90 | 25.45 | 83.55 | |
192 | Down | 95.24 | 20.00 | 50.00 | 83.33 | |
200b | Down | 86.31 | 28.21 | 32.35 | 83.82 |