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Table 1 Clinicopathological features of the study cohort

From: The effect of visceral obesity on clinicopathological features in patients with endometrial cancer: a retrospective analysis of 200 Chinese patients

Parameters

Cohort

VAT% < 31.89 %

VAT% ≥ 31.89 %

P value

N = 200

N = 100

N = 100

Median age (range), years

54 (28–84)

52 (28–82)

57 (34–84)

<0.001 a

Premenopausal patients (%)

83 (41.5 %)

52 (52.0 %)

31 (31.0 %)

0.003 b

Hypertension (%)

57 (28.5 %)

19 (19.0 %)

38 (38.0 %)

0.003 b

Diabetes (%)

27 (13.5 %)

9 (9.0 %)

18 (18.0 %)

0.063b

Positive peritoneal cytology (%)

16 (9.4 %) n = 171

10 (11.6 %) n = 86

6 (7.1 %) n = 85

0.305b

Histology

 Endometrioid (%)

181 (90.5 %)

92 (92.0 %)

89 (89.0 %)

0.381c

 Serous (%)

13 (6.5 %)

4 (4.0 %)

9 (9.0 %)

 Clear cell (%)

4 (2.0 %)

3 (3.0 %)

1 (1.0 %)

 Mucinous (%)

2 (1.0 %)

1 (1.0 %)

1 (1.0 %)

Histological grade

 Grade 1

86 (43.0 %)

48 (48.0 %)

38 (38.0 %)

0.069b

 Grade 2

85 (42.5 %)

43 (43.0 %)

42 (42.0 %)

 Grade 3

29 (14.5 %)

9 (9.0 %)

20 (20.0 %)

Deep myometrial invasion (≥50 %) (%)

46 (23.0 %)

18 (18.0 %)

28 (28.0 %)

0.093b

Average tumor size (range), cm

3.14 (0.2–20)

3.19 (0.3–12)

3.09 (0.2–20)

0.791a

n = 165d

n = 84d

n = 81d

LN metastasis

22 (11.0 %)

6 (6.0 %)

16 (16.0 %)

0.024 b

Median No. retrieved LNs (range)

25 (4–56)

26 (4–55)

24 (4–56)

0.160a

Lympho-vascular invasion (%)

37 (19.9 %) n = 186

17 (18.3 %) n = 93

20 (21.5 %) n = 93

0.582b

Extrauterine disease (%)

28 (14.0 %)

9 (9.0 %)

19 (19.0 %)

0.042 b

FIGO stage

 IA (%)

134 (67.0 %)

73 (73.0 %)

61 (61.0 %)

 

 IB (%)

23 (11.5 %)

11 (11.0 %)

12 (12.0 %)

 II (%)

15 (7.5 %)

7 (7.0 %)

8 (8.0 %)

 IIIA (%)

3 (1.5 %)

2 (2.0 %)

1 (1.0 %)

 IIIB (%)

2 (1.0 %)

1 (1.0 %)

1 (1.0 %)

 IIIC (%)

23 (11.5 %)

6 (6.0 %)

17 (17.0 %)

Median BMI (range), kg/m2

24.7 (17.5–43.7)

24.6 (18.03–43.7)

24.83 (17.53–35.16)

0.280a

Median VAT (range), mm2

17338 (5990–37118)

13780 (5990–31708)

20187(6649–37188)

<0.001 a

Median SAT (range), mm2

35607 (10458–106902)

41395 (20347–106902)

30360 (10458–61074)

<0.001 a

Median VAT% (range)

31.89 (13.97–59.57)

25.99 (13.97–31.88)

38.78(31.90–59.57)

<0.001 a

  1. aStudent’s T test
  2. bPearson Chi-square test
  3. cLikelihood ratio
  4. dNot all patients have tumor size recorded in the pathology report. Tumor confined within endometrium was reported without tumor size in 14 cases (7 and 7 in high and low VAT% group, respectively). A total of 21 patients (9 and 12 in high and low VAT% group, respectively) did not have tumor lesion in the final pathology after dilation and curettage
  5. Abbreviations: LN lymph node, BMI body mass index, SAT subcutaneous Adipose Tissue, VAT visceral adipose tissue, VAT % percentage of visceral adipose tissue
  6. Bold value denotes P with statistical significance