Local iron homeostasis in the breast ductal carcinoma microenvironment

BMC Cancer

Table 4 FPN1 expression in epithelial cells and macrophages in carcinomas according to clinicopathological variables

	DCIS (Mean ± SEM)				IDC (Mean ± SEM)
Clinicopathological variable	EC	Significance level.	M0	Significance level.	EC	Significance level.	M0	Significance level.
ER status	n = 22	ns	n = 14	p = 0.033	n = 103	p = 0.018	n = 73	ns
ER-	6.29 ± 0.65		13.04 ± 0.87		7.47 ± 0.88		7.17 ± 0.95
ER+	4.51 ± 0.43		7.75 ± 2.14		5.18 ± 0.31		6.01 ± 0.34
PR status	n = 22	ns	n = 14	ns	n = 103	ns	n = 73	ns
PR-	6.01 ± 0.61		11.59 ± 1.64		6.47 ± 0.65		7.25 ± 0.77
PR+	4.48 ± 0.46		9.30 ± 1.80		5.40 ± 0.36		5.83 ± 0.35
HER2 status	n = 22	ns	n = 14	ns	n = 101	p = 0.001	n = 73	ns
HER2-	5.76 ± 0.63		9.00 ± 2.45		5.21 ± 0.35		6.02 ± 0.38
HER2+	4.98 ± 0.57		11.76 ± 1.34		7.47 ± 0.64		6.89 ± 0.74

Abbreviations: DCIS Ductal Carcinoma In Situ, IDC Invasive Ductal Carcinoma, ER Estrogen Receptor, PR Progesterone Receptor, HER2 Human Epidermal growth factor Receptor 2, EC Epithelial Cells, Ly Lymphocytes, M0 Macrophages, FPN1 Ferroportin 1, TFR1 Transferrin Receptor 1, FT Ferritin, ns Not Statistically Significant, SEM Standard Error of the Mean

ISSN: 1471-2407