Fig. 3

Multiple chemotherapy agents induce RNA disruption in breast and ovarian cancer cell lines. Multiple breast and ovarian cancer cell lines were exposed to various chemotherapy agents and total RNA was isolated from the cells following drug exposure. a Gel image of total RNA isolated from A2780 cells treated with multiple chemotherapy agents. All treatments were for 72 h, except carboplatin, which was treated for 120 h. b Gel image of RNA isolated from MDA-MB-231, a breast cancer cell line, following treatment with multiple chemotherapy agents. All treatments were for 72 h, except for the control (0 μM) and cisplatin which were treated for 96 h. c Gel image of RNA isolated from various breast (MCF-7, MB231, SKBR3, BT474) and ovarian cancer (A2780, CaOV3) cells following 72 h docetaxel treatment, except for MDA-MB-231-0 μM, from which RNA was isolated after 96 h. Abbreviations: TAX-paclitaxel, DXL-docetaxel, CBN-carboplatin, CIS-cisplatin, ETOP-etoposide, VIN-vincristine, IRN-irinotecan, DOX-doxorubicin