Characterization of various cell lines from different ampullary cancer subtypes and cancer associated fibroblast-mediated responses

Table 6 Gene Ontology (GO) functional enrichment analysis regulated proteins in ampullary cancer cells SNU869

GO terms of up-regulated proteins	Count	FDR
GO:0071840 Cellular component organization or biogenesis	148	4.19E-07
GO:0061024 Membrane organization	47	7.99E-07
GO:0016043 Cellular component organization	143	7.99E-07
GO:0044238 Primary metabolic process	216	2.47E-06
GO:0044237 Cellular metabolic process	213	2.83E-06
GO:0045184 Establishment of protein localization	58	3.67E-06
GO terms of down-regulated proteins	count	FDR
GO0043043: Peptide biosynthetic process	30	1.18E-10
GO:0006412 Translation	29	1.18E-10
GO:0043604 Amide biosynthetic process	31	5.81E-10
GO:1901564 Organonitrogen compound metabolic process	61	1.24E-09
GO:0007005 Mitochondrion organization	29	3.54E-09
GO:0006518 Peptide metabolic process	30	5.57E-09

Enrichment is analyzed using all differentially expressed proteins with fold-change of greater than 50 % SNU869 cells cultivated in CAF-conditioned medium versus non-treated control cells (log₂ ratio of > 0.58, p-value < 0.1, two-tailed t-test, FDR < 0.05)
Abbreviations: CAF cancer associated fibroblast, FDR false discovery rate

ISSN: 1471-2407