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Table 1 Overview of pancreatic panniculitides described in English literature between January 1994 and November 2014

From: Pancreatic panniculitis in a patient with pancreatic-type acinar cell carcinoma of the liver – case report and review of literature

Patient

Ref.

Age

Sex

Underlying condition

Outcome of skin lesions/follow-up

1

our pat.

73

f

ACC of the liver

death ten weeks after first skin lesion

2

[53]

55

m

metastatic pancreatic NEC

n.r.

3

[54]

38

m

acute pancreatitis

resolution

4

[7]

63

m

acute pancreatitis

resolution

5

[55]

81

f

hemosuccus pancreaticus

death 19 weeks after first skin lesion

6

[56]

26

f

acute pancreatitis

resolution

7

[57]

27

f

acute pancreatitis

resolution

8

[58]

34

m

chronic pancreatitis

n.r.

9

[59]

63

f

acute pancreatitis

resolution

10

[60]

83

m

pancreatic ACC

resolution of skin lesions after surgery, death 34 months after first skin lesion

11

[60]

75

m

Acute pancreatitis

resolution

12

[60]

60

m

Large pancreatic neoplasm

n.r.

13

[61]

68

f

metastatic pancreatic ACC

death six months after first skin lesion

14

[62]

61

f

acute pancreatitis

resolution

15

[63]

63

f

acute pancreatitis

resolution

16

[64]

49

m

acute pancreatitis

resolution

17

[47]

69

m

hepatic metastasis of previous-ly resected pancreatic ACC

resolution after metastasectomy, follow-up n.r.

18

[65]

71

f

chronic pancreatitis with pseudocyst

n.r.

19

[66]

66

f

serous cystadenoma of the pancreas

n.r.

20

[67]

39

m

chronic pancreatitis

death six weeks after first skin lesion

21

[68]

20

f

pseudopapillary pancreatic tumor, chronic pancreatitis

death eleven weeks after first skin lesion

22

[8]

38

f

acute pancreatitis

resolution

23

[69]

56

f

acute pancreatitis

death within a few days

24

[70]

79

m

pancreatic ACC

n.r.

25

[71]

17

f

acute pancreatitis

resolution

26

[72]

54

m

pancreatic ACC

Response to octreotide, regression of skin lesions after resection, follow-up two months (i.e. eleven months after first skin lesion)

27

[73]

81

f

pancreatic tumor with hepatic metastases

n.r.

28

[74]

64

m

anastomotic leakage after Whipple procedure

death 50 days after first skin lesion

29

[75]

79

f

pancreatic ACC

regression after resection, follow-up 14 months after resection (i.e. 16 months after first skin lesion)

30

[35]

60

f

pancreatic adenocarcinoma

n.r.

31

[35]

58

m

malignant neoplasia of the tail of the pancreas

n.r.

32

[76]

44

f

pancreas transplant rejection

resolution

33

[77]

63

f

metastatic pancreatic adenocarcinoma

n.r.

34

[78]

38

m

pancreatic pseudocyst-inferior vena cava fistula

resolution after Roux-en-Y pseudocyst-jejunostomy

35

[40]

82

m

pancreatic ACC

death 2.5 months after first skin lesion

36

[46]

79

m

pancreatic ACC

death two months after first skin lesion

37

[79]

2,5

m

acute pancreatitis with pseudocyst

n.r.

38

[80]

45

m

chronic pancreatitis

resolution after placement of endoprothesis

39

[81]

18

w

acute pancreatitis

resolution

40

[82]

10

w

acute pancreatitis with pseudocyst

resolution after endosonographic cysto-gastrostomy

41

[83]

69

m

gastric adenocarcinoma with pancreas metastasis

death 14 weeks after first skin lesion

42

[84]

58

m

pancreatic pseudocyst-portal vein fistula

death five days after admission

43

[85]

84

m

pancreatic tumor

death two months after first skin lesion

44

[86]

40

m

chronic pancreatitis

n.r.

45

[87]

84

f

acute pancreatitis, liver lesions ten years after resection of colonic carcinoma

initially resolution, death three months later

46

[2]

65

f

acute pancreatitis

death from gangrenous cholecystitis

47

[2]

64

f

acute pancreatitis

resolution

48

[2]

70

f

pancreatic carcinoma

death

49

[2]

58

m

pancreatic carcinoma

death

50

[2]

21

f

pancreatic carcinoma

death

51

[2]

75

m

acute pancreatitis

death

52

[2]

75

f

acute pancreatitis

resolution

53

[2]

44

m

chronic pancreatitis

resolution

54

[2]

63

m

pancreatic carcinoma

death

55

[2]

72

m

pancreatic carcinoma

death

56

[2]

60

m

pancreatic carcinoma

n.r.

57

[88]

35

m

chronic pancreatitis

n.r.

58

[89]

7

m

acute pancreatitis

resolution

59

[14]

61

m

metastatic NEC of unknown primary site

death a few weeks after first skin lesion

60

[42]

50

f

metastatic ACC

regression of skin lesions and tumor under octreotide, gemcitabine, streptozocin and doxorubicin; return after discontinuation; response to restart of therapy; follow-up 9 months after first skin lesion

61

[90]

74

m

pancreatic ACC

death 3.75 months after first skin lesion

62

[91]

61

m

metastatic ACC

n.r.

63

[92]

79

m

metastatic pancreatic NEC

Regression under cefazolin, dexamethasone and NSAID; death 13 months after first skin lesion

64

[93]

50

m

acute pancreatitis

death 38 days after first skin lesion

65

[94]

4

m

acute pancreatitis

resolution

66

[11]

45

m

acute pancreatitis

Regression under NSAID and prednisone

67

[95]

72

m

acute pancreatitis

resolution

68

[96]

52

f

pancreatic carcinoma

death six months after first skin lesion

69

[97]

29

m

acute pancreatitis

resolution

70

[23]

75

f

hepatic metastases of adeno-carcinoma of unknown origin

death 15 weeks after first skin lesion

71

[6]

78

m

metastatic pancreatic NEC

death two months after first skin lesion

72

[6]

75

m

pancreatic adenocarcinoma

regression under irradiation, follow-up n.r.

73

[98]

67

f

IPMN

partial pancreatectomy, follow-up n.r.

74

[99]

51

m

chronic pancreatitis

regression of skin lesions under conservative treatment

75

[100]

49

f

pancreas transplant rejection

resolution

76

[101]

89

f

acute pancreatitis

resolution

77

[42]

59

m

hepatic metastases of pre-viously resected pancreatic ACC

death several weeks after first skin lesion

78

[102]

67

m

metastatic pancreatic adenocarcinoma

regression under irinotecan, cisplatin, mito-mycin; death twelve months after first skin lesion

79

[103]

62

f

IPMN

resection, follow-up n.r.

80

[22]

60

m

metastatic pancreatic acinar cell cystadenocarcinoma

death seven weeks after admission

81

[104]

13

m

chronic pancreatitis with pseudocyst

regression after cystogastrostomy

82

[41]

72

m

pancreatic NEC

regression after resection, no reappearance with liver metastases, death 15 months after first skin lesion

83

[25]

58

m

HCC

death four months after first skin lesion

84

[105]

88

m

metastatic pancreatic NEC

Death eight weeks after first skin lesion

85

[106]

42

f

acute pancreatitis

resolution

86

[107]

63

m

chronic pancreatitis

resolution after distal pancreatectomy and pancreatic duct dilation

87

[108]

34

m

acute pancreatitis

resolution

88

[109]

21

f

acute pancreatitis

death from retroperitoneal hemorrhage

89

[110]

61

f

metastatic pancreatic ACC

death one year after first skin lesion

90

[3]

70

f

IPMN

resolution after resection

91

[3]

53

f

IPMN

resolution after resection

92

[111]

37

f

acute pancreatitis with pseudocyst

resolution after surgery

93

[111]

50

m

acute pancreatitis with pseudocyst

resolution after stone extraction from the pancreatic duct

94

[112]

71

m

pancreatic adenocarcinoma

n.r.

95

[113]

60

f

pancreatic ACC

regression after distal pancreatectomy, follow-up 28 months after first skin lesion

96

[113]

54

m

pancreatic ACC

death six weeks after first skin lesion

97

[114]

56

m

chronic pancreatitis

n.r.

98

[115]

53

m

actue pancreatitis

resolution

99

[48]

67

m

metastatic pancreatic ACC

Regression after TACE of four liver metasta-ses, death 14 weeks after first skin lesion

100

[116]

n.r.

n.r.

chronic pancreatitis

resolution after placement of pancreatic duct stent

101

[117]

31

m

acute pancreatitis

resolution

102

[118]

57

f

acute pancreatitis

resolution

103

[119]

60

f

pancreatic ACC

resolution after resection, follow-up n.r.

104

[120]

41

m

acute pancreatitis

death 22 days after admission

105

[44]

79

f

metastatic pancreatic ACC

Death 20 weeks after first skin lesion

106

[121]

45

m

chronic pancreatitis

resolution

107

[122]

59

f

acute pancreatitis

resolution

108

[123]

81

m

pancreatic ACC

n.r.

109

[124]

69

m

pancreatic ACC

n.r.

110

[125]

15

f

acute pancreatitis

death nine days after first skin lesion

111

[126]

49

m

acute pancreatitis

regression under antibiotic treatment, then slight progression, follow-up seven weeks

112

[127]

66

m

pancreatic ACC

resolution after resection, follow-up n.r.

113

[128]

67

m

chronic pancreatitis

death two months after first skin lesion

114

[12]

69

m

pancreatic ACC

resolution after distal pancreatectomy and adjuvant radio-chemotherapy, follow-up 6 months

115

[129]

29

f

acute pancreatitis

resolution

116

[130]

29

m

pancreatic pseudocyst-portal vein fistula

no new lesions after surgery

117

[131]

75

m

pancreatic tumor

Death several months after first skin lesion

118

[131]

39

m

chronic pancreatitis with pseudocyst

n.r.

119

[132]

62

m

acute pancreatitis

resolution

120

[133]

77

f

pancreatic tumor

death five months after first skin lesion

121

[134]

54

f

chronic pancreatitis

resolution after ESWL and endoscopic dilation of the pancreatic duct

122

[135]

47

f

acute pancreatitis

resolution

123

[136]

7

m

acute pancreatitis

n.r.

124

[137]

69

m

chronic pancreatitis with pseudocyst

resolution

125

[138]

33

f

acute pancreatitis

n.r.

126

[139]

46

f

chronic pancreatitis

death four months after first skin lesion

127

[140]

55

m

chronic pancreatitis

n.r.

128

[5]

62

m

acute pancreatitis

resolution

129

[141]

61

f

metastatic ACC

resolution after surgery, follow-up n.r.

130

[142]

80

m

pancreatic ACC

resolution after surgery, death from metastatic disease after 18 months

131

[143]

n.r.

m

pancreatic ACC

n.r.