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Table 2 Selectivity Index of Cisplatin and active Cisplatin (IV) prodrugs. The IC50s of Cisplatin, RJY6 and RJY13 were determined using A2780, HFF, HEK293A and HEK293T cells. Data shown are of representative of three experiments with CV below 20 % in all samples

From: Platinum (IV)-fatty acid conjugates overcome inherently and acquired Cisplatin resistant cancer cell lines: an in-vitro study

 

IC50 (μM)

Compound

A2780

HFF

HEK293T

HEK293A

Cisplatin

1.3

84

3.2

16.3

Carboplatin

16.8

ND

45

105

RJY6

0.7

82

11.8

17.3

RJY13

0.08

2.4

0.5

0.7

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BMC Cancer

ISSN: 1471-2407

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