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Table 2 Selectivity Index of Cisplatin and active Cisplatin (IV) prodrugs. The IC50s of Cisplatin, RJY6 and RJY13 were determined using A2780, HFF, HEK293A and HEK293T cells. Data shown are of representative of three experiments with CV below 20 % in all samples

From: Platinum (IV)-fatty acid conjugates overcome inherently and acquired Cisplatin resistant cancer cell lines: an in-vitro study

  IC50 (μM)
Compound A2780 HFF HEK293T HEK293A
Cisplatin 1.3 84 3.2 16.3
Carboplatin 16.8 ND 45 105
RJY6 0.7 82 11.8 17.3
RJY13 0.08 2.4 0.5 0.7