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Table 1 Patients’ and tumor characteristics and univariate statistical analysis of disease-specific survival

From: Treatment and outcome of 32 patients with distant metastases of Hürthle cell thyroid carcinoma: a single-institution experience

Factor

Subgroup

Initially metastatic (N = 12)

Distant progression (N = 20)

p-value

Gender

Female

9

10

0.16

Male

3

10

Age at presentation (years)

64 or less

6

5

0.15

65 or more

6

15

Tumor diameter (cm)

0-4

3

4

0.74

4.01 and more

9

16

pT tumor stage

pT0 or pT2

2

3

0.96

pT3

6

11

pT4

4

6

N stage

N0

10

16

0.48

N1 (N1a + N1b)

2

4

M stage

M0

12

0

-

M1

0

20

Thyroid surgical procedure

Total or near-total thyroidectomy

6

13

0.40

Lobectomy or less

6

7

Neck dissection

No

9

18

0.26

Yes

3

2

Residual tumor after surgery

R0 – without residual tumor

3

12

0.066

R1 – microscopic residual tumor

8

5

R2– macroscopic residual tumor

1

3

Radioiodine ablation after surgery

No

1

1

0.71

Yes

11

19

Therapy with radioiodine

No

5

8

0.93

Yes

7

12

External beam irradiation - neck

No

6

14

0.40

Yes

6

6

External beam irradiation – any site

No

2

11

0.03

Yes

10

9

Chemotherapy

No

4

16

0.008

Yes

8

4

Outcome

Alive without disease

0

0

-

Alive with disease

2

9

Dead of disease

9

11

Dead of other causes

0

0

Lost to follow-up

1

0