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Table 1 Patients’ and tumor characteristics and univariate statistical analysis of disease-specific survival

From: Treatment and outcome of 32 patients with distant metastases of Hürthle cell thyroid carcinoma: a single-institution experience

Factor Subgroup Initially metastatic (N = 12) Distant progression (N = 20) p-value
Gender Female 9 10 0.16
Male 3 10
Age at presentation (years) 64 or less 6 5 0.15
65 or more 6 15
Tumor diameter (cm) 0-4 3 4 0.74
4.01 and more 9 16
pT tumor stage pT0 or pT2 2 3 0.96
pT3 6 11
pT4 4 6
N stage N0 10 16 0.48
N1 (N1a + N1b) 2 4
M stage M0 12 0 -
M1 0 20
Thyroid surgical procedure Total or near-total thyroidectomy 6 13 0.40
Lobectomy or less 6 7
Neck dissection No 9 18 0.26
Yes 3 2
Residual tumor after surgery R0 – without residual tumor 3 12 0.066
R1 – microscopic residual tumor 8 5
R2– macroscopic residual tumor 1 3
Radioiodine ablation after surgery No 1 1 0.71
Yes 11 19
Therapy with radioiodine No 5 8 0.93
Yes 7 12
External beam irradiation - neck No 6 14 0.40
Yes 6 6
External beam irradiation – any site No 2 11 0.03
Yes 10 9
Chemotherapy No 4 16 0.008
Yes 8 4
Outcome Alive without disease 0 0 -
Alive with disease 2 9
Dead of disease 9 11
Dead of other causes 0 0
Lost to follow-up 1 0