Characteristics | OCT1 (SLC22A1) | OCT1 (SLC22A1) | P-value |
---|---|---|---|
Low expression | High expression | ||
(< lower quartile) | (≥ lower quartile) | ||
n | 15 | 45 | |
Gender | |||
male | 14 | 40 | |
female | 1 | 5 | 1.000 (Fisher’s exact test) |
Mean age | |||
years (standard deviation) | 65.022 (7.190) | 64.658 (11.667) | 0.910 (unpaired t test) |
Underlying liver disease | |||
alcohol | 2 | 14 | |
HBV | 3 | 8 | |
HCV | 4 | 8 | |
steatosis or NASH | 0 | 5 | |
others | 5 | 6 | |
unknown | 1 | 4 | 0.224 (Fisher’s exact test) |
Prior HCC treatment | |||
yes | 6 | 29 | |
no | 9 | 16 | 0.133 (Fisher’s exact test) |
Tumor grading | |||
G1 | 3 | 10 | |
G2 | 8 | 26 | |
G3 | 4 | 4 | |
unknown | 0 | 5 | 0.265 (Mann–Whitney U test) |
Tumor burden | |||
MVI absent | 4 | 27 | |
present | 11 | 18 | 0.037 (Fisher’s exact test) |
EHS absent | 5 | 12 | |
present | 10 | 33 | 0.743 (Fisher’s exact test) |
MVI | |||
and/or EHS absent | 1 | 5 | |
present | 14 | 40 | 1.000 (Fisher’s exact test) |
BCLC classification | |||
A | 0 | 1 | |
B | 1 | 0 | |
C | 12 | 38 | |
D | 2 | 4 | |
unknown | 0 | 2 | 0.988 (Mann–Whitney U test) |
ECOG PS | |||
0 | 2 | 9 | |
1 | 8 | 31 | |
2 | 2 | 3 | |
3 | 2 | 0 | |
unknown | 1 | 2 | 0.099 (Mann–Whitney U test) |
Child-Pugh | |||
A | 1 | 13 | |
B | 11 | 13 | |
C | 0 | 4 | |
unkown | 3 | 15 | 0.195 (Mann–Whitney U test) |
Ascites | |||
absent | 5 | 18 | |
present | 6 | 13 | |
unknown | 4 | 14 | 0.504 (Fisher’s exact test) |
Baseline AFP (ng/ml) | |||
≤20 | 2 | 20 | |
>20 | 11 | 25 | |
unknown | 2 | 0 | 0.103 (Fisher’s exact test) |
mean duration | |||
sorafenib treatment | |||
days (standard deviation) | 161 (126) | 149 (128) | 0.764 (unpaired t test) |