Table 2 Correlation between either epithelial or stromal PN expression and clinical-pathological variables
Epithelial Expression (% cells stained) | Stromal Expression (% cells stained) | |||||
|---|---|---|---|---|---|---|
Negativea | Positivea | p= | Lowa | Higha | p= | |
n = 120 | n = 80 | n = 99 | n = 101 | |||
Median age at surgery, years | ||||||
≤ 58 | 64 (53.3 %) | 39 (48.8 %) | 0.6 | 57 (57.6 %) | 46 (45.5 %) | 0.1 |
> 58 | 56 (46.7 %) | 41 (51.2 %) | 42 (42.4 %) | 55 (54.5 %) | ||
Menopausal status | ||||||
Pre-menopausal | 41 (34.2 %) | 22 (27.5 %) | 0.3 | 35 (35.4 %) | 28 (27.7 %) | 0.3 |
Post-menopausal | 79 (65.8 %) | 58 (72.5 %) | 64 (64.6 %) | 73 (72.3 %) | ||
Tumour size: cm in diameter | ||||||
≤ 2 | 61 (50.8 %) | 33 (41.3 %) | 0.2 | 51 (51.5 %) | 43 (42.6 %) | 0.2 |
> 2 | 59 (49.2 %) | 47 (58.7 %) | 48 (48.5 %) | 58 (57.4 %) | ||
Nodal status | ||||||
Node-negative | 60 (50.0 %) | 45 (56.3 %) | 0.4 | 50 (50.5 %) | 55 (54.5 %) | 0.6 |
Node-positive | 60 (50.0 %) | 35 (43.7 %) | 49 (49.5 %) | 46 (45.5 %) | ||
ER status | ||||||
Poor | 29 (24.2 %) | 13 (16.3 %) | 0.2 | 23 (23.2 %) | 19 (18.8 %) | 0.4 |
Rich | 91 (75.8 %) | 67 (83.7 %) | 76 (76.8 %) | 82 (81.2 %) | ||
PgR status | ||||||
Poor | 50 (41.7 %) | 36 (45.0 %) | 0.6 | 46 (46.5 %) | 40 (39.6 %) | 0.3 |
Rich | 70 (58.3 %) | 44 (55.0 %) | 53 (53.5 %) | 61 (60.4 %) | ||
Ki-67 | ||||||
Low | 53 (44.2 %) | 38 (47.5 %) | 0.6 | 44 (44.4 %) | 47 (46.5 %) | 0.7 |
High | 67 (55.8 %) | 42 (52.5 %) | 55 (55.6 %) | 54 (53.5 %) | ||
HER2 status | ||||||
Negative | 110 (91.7 %) | 73 (91.3 %) | 0.9 | 88 (88.9 %) | 95 (94.1 %) | 0.2 |
Positive | 10 (8.3 %) | 7 (8.7 %) | 11 (11.1 %) | 6 (5.9 %) | ||
Phenotypeb | ||||||
Luminal A | 39 (32.5 %) | 25 (31.3 %) | 0.6 | 29 (29.3 %) | 35 (34.7 %) | 0.7 |
Luminal B (HER2-neg) | 47 (39.2 %) | 38 (47.5 %) | 41 (41.4 %) | 44 (43.6 %) | ||
Luminal B (HER2-pos) | 5 (4.2 %) | 4 (5.0 %) | 6 (6.1 %) | 3 (3.0 %) | ||
HER2 positive (non luminal) | 5 (4.2 %) | 3 (3.7 %) | 5 (5.1 %) | 3 (3.0 %) | ||
Triple negative | 24 (20.0 %) | 10 (12.5 %) | 18 (18.2 %) | 16 (15.8 %) | ||
Adjuvant systemic therapyc | ||||||
No | 48 (40.0 %) | 39 (48.8 %) | 0.2 | 43 (43.4 %) | 44 (43.6 %) | 0.9 |
Yes | 72 (60.0 %) | 41 (51.2 %) | 56 (56.6 %) | 57 (56.4 %) | ||