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Table 2 Correlation between either epithelial or stromal PN expression and clinical-pathological variables

From: The prognostic value of stromal and epithelial periostin expression in human breast cancer: correlation with clinical pathological features and mortality outcome

  Epithelial Expression (% cells stained) Stromal Expression (% cells stained)
  Negativea Positivea p= Lowa Higha p=
  n = 120 n = 80   n = 99 n = 101  
Median age at surgery, years
 ≤ 58 64 (53.3 %) 39 (48.8 %) 0.6 57 (57.6 %) 46 (45.5 %) 0.1
 > 58 56 (46.7 %) 41 (51.2 %) 42 (42.4 %) 55 (54.5 %)
Menopausal status
 Pre-menopausal 41 (34.2 %) 22 (27.5 %) 0.3 35 (35.4 %) 28 (27.7 %) 0.3
 Post-menopausal 79 (65.8 %) 58 (72.5 %) 64 (64.6 %) 73 (72.3 %)
Tumour size: cm in diameter
 ≤ 2 61 (50.8 %) 33 (41.3 %) 0.2 51 (51.5 %) 43 (42.6 %) 0.2
 > 2 59 (49.2 %) 47 (58.7 %) 48 (48.5 %) 58 (57.4 %)
Nodal status
 Node-negative 60 (50.0 %) 45 (56.3 %) 0.4 50 (50.5 %) 55 (54.5 %) 0.6
 Node-positive 60 (50.0 %) 35 (43.7 %) 49 (49.5 %) 46 (45.5 %)
ER status
 Poor 29 (24.2 %) 13 (16.3 %) 0.2 23 (23.2 %) 19 (18.8 %) 0.4
 Rich 91 (75.8 %) 67 (83.7 %) 76 (76.8 %) 82 (81.2 %)
PgR status
 Poor 50 (41.7 %) 36 (45.0 %) 0.6 46 (46.5 %) 40 (39.6 %) 0.3
 Rich 70 (58.3 %) 44 (55.0 %) 53 (53.5 %) 61 (60.4 %)
Ki-67
 Low 53 (44.2 %) 38 (47.5 %) 0.6 44 (44.4 %) 47 (46.5 %) 0.7
 High 67 (55.8 %) 42 (52.5 %) 55 (55.6 %) 54 (53.5 %)
HER2 status
 Negative 110 (91.7 %) 73 (91.3 %) 0.9 88 (88.9 %) 95 (94.1 %) 0.2
 Positive 10 (8.3 %) 7 (8.7 %) 11 (11.1 %) 6 (5.9 %)
Phenotypeb
 Luminal A 39 (32.5 %) 25 (31.3 %) 0.6 29 (29.3 %) 35 (34.7 %) 0.7
 Luminal B (HER2-neg) 47 (39.2 %) 38 (47.5 %) 41 (41.4 %) 44 (43.6 %)
 Luminal B (HER2-pos) 5 (4.2 %) 4 (5.0 %) 6 (6.1 %) 3 (3.0 %)
 HER2 positive (non luminal) 5 (4.2 %) 3 (3.7 %) 5 (5.1 %) 3 (3.0 %)
 Triple negative 24 (20.0 %) 10 (12.5 %) 18 (18.2 %) 16 (15.8 %)
Adjuvant systemic therapyc
 No 48 (40.0 %) 39 (48.8 %) 0.2 43 (43.4 %) 44 (43.6 %) 0.9
 Yes 72 (60.0 %) 41 (51.2 %) 56 (56.6 %) 57 (56.4 %)
  1. aNegative: 0 % of stained cells; positive: at least 1 % of stained cells; low: less than 90 % of stained cells; high: more or equal to 90 % of stained cells
  2. bdefinition of intrinsic subtypes of breast cancer according to [23]
  3. ceither chemotherapy or endocrine therapy or both