Table 2 Summary of MET status and sensitivity to ABT-700 in a panel of 35 human cancer lines
From: Anti-c-Met monoclonal antibody ABT-700 breaks oncogene addiction in tumors with MET amplification
Cell line | Type | Source | FISH | WB | Proliferation | Â | |||
|---|---|---|---|---|---|---|---|---|---|
| Â | Â | Â | MET (mean/cell) | CEP7 (mean/cell) | Ratio MET/CEP7 | Total c-Meta | Phospho-(Y1234) c-Meta | Max Inhibition by (%) | |
| Â | Â | Â | Â | Â | Â | Â | Â | PF-4217903b | ABT-700c |
SNU620 | gastric | KCLB | 41.6 | 4.4 | 10.6 | 6.7 | 56 | 95 | 80 |
H1993 | lung | ATCC | 32 | 11.9 | 2.8 | 5.4 | 829 | 50 | 30 |
Hs746T | gastric | ATCC | 22.2 | 3.9 | 6.6 | 6 | 377 | 55 | 40 |
OE33 | esophageal | Sigma | 21.4 | 6.9 | 3.1 | 6 | 430 | 60 | 70 |
SNU5 | gastric | ATCC | 20.2 | 7.9 | 2.6 | 12 | 910 | 95 | 90 |
EBC1 | lung | JCRB | 15.6 | 3.1 | 5.2 | 6 | 374 | 85 | 30 |
MKN45 | gastric | JCRB | 12.6 | 3.4 | 4 | 10 | 297 | 96 | 50 |
H1573 | lung | ATCC | 11.5 | 4.3 | 2.7 | 1.8 | 5 | 0 | 0 |
H2342 | lung | ATCC | 8.6 | 5.2 | 1.7 | 0.7 | 1.3 | 0 | 0 |
H820 | lung | ATCC | 8.3 | 5 | 1.7 | 2.9 | 5.7 | 20 | 0 |
NUGC-2 | gastric | JCRB | 7.8 | 8.2 | 1 | 0.5 | 0.1 | 0 | 0 |
FU97 | gastric | JCRB | 7.6 | 7.5 | 1 | 0.1 | 0.1 | 0 | 0 |
NUGC-4 | gastric | JCRB | 6 | 5.1 | 1.3 | 1 | 15 | 50 | 0 |
SNU-16 | gastric | ATCC | 5.1 | 5.7 | 0.9 | 0.5 | 2.5 | 0 | 0 |
KATOIII | gastric | ATCC | 4.6 | 5 | 0.9 | 0.9 | 16 | 0 | 0 |
SNU-216 | gastric | KCLB | 4.5 | 4.7 | 1 | 0.8 | 0.5 | 0 | 0 |
MKN-1 | gastric | JCRB | 4.4 | 3.8 | 1.2 | 0.2 | 0.1 | 0 | 0 |
SNU-484 | gastric | KCLB | 4.2 | 4 | 1 | 0.1 | 0.1 | 0 | 0 |
SNU-668 | gastric | KCLB | 3.6 | 3.6 | 1 | 1.9 | 0.5 | 0 | 0 |
SNU-1 | gastric | ATCC | 3.3 | 3.2 | 1 | NA | NA | 0 | 0 |
RERF-GC-1B | gastric | JCRB | 3.1 | 4.2 | 0.8 | 0.6 | 0.6 | 0 | 0 |
OCUM-1 | gastric | JCRB | 3 | 2.9 | 1 | 0.4 | 0.3 | 0 | 0 |
SCH | gastric | JCRB | 3 | 3.5 | 0.9 | 0.3 | 0 | 0 | 0 |
NCC-StC-K140 | gastric | JCRB | 2.8 | 9 | 0.3 | 0.5 | 0.3 | 30 | 0 |
SNU-719 | gastric | KCLB | 2.7 | 3.5 | 0.8 | 0.4 | 0.1 | 0 | 0 |
IM95 | gastric | JCRB | 2.5 | 2.5 | 1.1 | 0.2 | 0.5 | 90 | 60 |
MKN74 | gastric | JCRB | 2.4 | 2.6 | 1 | 0.1 | 0.1 | 0 | 0 |
SNU-601 | gastric | KCLB | 2.4 | 3 | 0.8 | 0.4 | 2.6 | 0 | 0 |
U87MG | glioblastoma | ATCC | 2.1 | 2.1 | 1 | 0.5 | 3 | 30 | 30 |
23132/87 | gastric | DSMZ | 2 | 1.9 | 1.2 | 0.5 | 0.2 | 0 | 0 |
AGS | gastric | ATCC | 2 | 2.2 | 1 | 0.2 | 0.1 | 0 | 0 |
NUGC-3 | gastric | JCRB | 2 | 3.2 | 0.7 | 0.5 | 1.1 | 0 | 0 |
SNU638 | gastric | KCLB | 2 | 2 | 1 | 3.6 | 28 | 80 | 50 |
TAKIGAW | gastric | JCRB | 2 | 5.1 | 0.4 | 0.4 | 0.1 | 0 | 0 |
NCI-N87 | gastric | ATCC | 1 | 2 | 0.5 | NA | NA | 0 | 0 |
A549 | lung | ATCC | NA | NA | NA | 1 | 1 | 0 | 0 |