Fig. 5
From: Anti-c-Met monoclonal antibody ABT-700 breaks oncogene addiction in tumors with MET amplification
MET amplification as detected by FISH analysis in human gastric cancer specimens. a Venn diagram showing amplification frequency in a tissue microarray of gastric cancer samples of Asian patients. MET amplification was defined as average of MET/CEP 7 ratio ≥2 in chromosomally abnormal cells selected for enumeration. HER2 amplification was defined similarly but with the ratio of HER2/CEP 17 ≥ 2. b Composite image of a MET amplified gastric cancer sample. Insert shows clusters of amplified MET genes in the nuclei of tumor cells