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Table 2 Univariate and multivariate analysis of lymph node metastasis risk factors of early gastric cancer

From: A nomogram for predicting the likelihood of lymph node metastasis in early gastric patients

Clinicopathological features Univariate analysis p Multivariate analysis p
RR (95 % CI) RR (95 % CI)
Gender     
 Male vs. Female 1.038 (0.578–1.865) 0.901   
Age (years)     
 <50 vs. ≥50 0.514 (0.286–0.926) 0.027 0.444 (0.215–0.916) 0.028
Location     
 Upper 1/3 1.000 0.190   
 Middle 1/3 0.438 (0.168–1.143) 0.092   
 Lower 1/3 0.720 (0.367–1.415) 0.341   
Macroscopic type     
 I + II vs. III/Mixed 3.165 (1.758–5.696) <0.001   
Size (cm)     
 <2.0 vs. ≥2.0 2.298 (1.285–4.109) 0.005   
 <1.5 vs. ≥1.5 4.402 (1.960–9.885) <0.001   
Histology     
 Adenocarcinoma vs. Other typesa 2.408 (1.385–4.185) 0.002   
Differentiation     
 Differentiated vs. Undifferentiated 4.000 (1.982–8.072) <0.001 3.724 (1.637–8.470) 0.002
Ulcer     
 Absent vs. Present 3.206 (1.772–5.803) <0.001 2.710 (1.310–5.606) 0.007
Lymphovascular invasion     
 Absent vs. Present 20.192 (10.675–38.191) <0.001 13.703 (6.515–28.822) <0.001
Depth of invasion     
 Mucosa vs. Submucosa 7.290 (3.610–14.721) <0.001 3.013 (1.369–6.631) 0.006
  1. Other typesa: signet-ring cell carcinoma, mucinous adenocarcinoma, etc
  2. RR Relative risk
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