Fig. 3

Three-dimensional structure of the EcA protein with a color mapping representing the example of the epitope prediction obtained by EPSRV method (blue – low probability, red – high probability). Following key structural elements of the enzyme are designated in the figure: three N-terminal active site loops, two C-terminal active site loops, multi-subunit interface regions and inter-domain linker. Inset: Tetrameric structure of Escherichia coli L-asparaginase EcA