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Table 1 Distribution of demographic and risk factors in the patient cohorts with index OPC and non-OPC

From: Site disparities in apoptotic variants as predictors of risk for second primary malignancy in patients with squamous cell carcinoma of the head and neck

Variables Total OPC (N = 752) Non-OPC (N = 777)
No. SPM (N) % p* SPM (N) % p*
Total patients 1529 42 5.6   82 10.6  
Age     0.004    0.024
  ≤ Median (57 years) 770 12 28.6   33 40.2  
  > Median (57 years) 759 30 71.4   49 59.8  
Sex     0.546    0.170
 Male 1186 35 83.3   62 75.6  
 Female 343 7 16.7   20 24.4  
Tobacco smoking     0.010    0.037
 Ever 1009 22 52.4   69 84.1  
 Never 520 20 47.6   13 15.9  
Alcohol drinking     0.813    0.005
 Ever 1099 30 71.4   69 84.1  
 Never 430 12 28.6   13 15.9  
Ethnicity     0.598    0.028
 Non-Hispanic White 1333 38 90.5   60 73.2  
 Other 196 4 9.5   22 26.8  
Index cancer stage     0.240    0.035
 I or II 386 5 11.9   26 31.7  
 III or IV 1143 37 88.1   56 68.3  
Treatmenta     0.511    0.111
 S only 253 0 0.0   19 23.2  
 S/C/X 335 4 9.5   30 36.6  
 X/C 941 38 90.5   33 40.2  
  1. *χ2 test for differences between patients with and without SPM
  2. aS, surgery, C, chemotherapy, and X, radiation
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