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Table 5 Expression of E-cadherin, ICAM-1, VCAM-1 and CK8/18 in the tumors at surgery, upon implantation and during metastasis

From: Establishment and characterization of a metastasis model of human gastric cancer in nude mice

Variable

No

Protein expressiona

mRNA expressiona

E-cadherin

ICAM-1

VCAM-1

CK8/18

E-cadherin

ICAM-1

VCAM-1

surgical specimen

1

-

+++

+++

+++

   

Primary

1

       

 Implanted tumor

 

-

-

++

+

0

0

0.0927

 Metastatic tumor

 

-

-

-

-

0

0

0

1st

5

       

 Implanted tumor

 

− (0/5)

− (0/5)

+ (5/5)

− (0/5)

0

0

0.1997

 Metastatic tumor

 

− (0/5)

− (0/5)

− (5/5)

− (0/5)

0

0

0

2nd ~ 10th

45

       

 Implanted tumor

 

− (0/45)

− (0/45)

− (0/45)

− (0/45)

0

0

0

 Metastatic tumor

 

− (0/42)

− (0/42)

− (0/42)

− (0/42)

0

0

0

  1. aMolecular analysis of the implanted and metastatic tumors revealed no detectable expression of CK8/18, E-cadherin, VCAM-1 and ICAM-1, except positive staining for VCAM-1 in the implanted tumor tissues of the first generation