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Table 5 Expression of E-cadherin, ICAM-1, VCAM-1 and CK8/18 in the tumors at surgery, upon implantation and during metastasis

From: Establishment and characterization of a metastasis model of human gastric cancer in nude mice

Variable No Protein expressiona mRNA expressiona
E-cadherin ICAM-1 VCAM-1 CK8/18 E-cadherin ICAM-1 VCAM-1
surgical specimen 1 - +++ +++ +++    
Primary 1        
 Implanted tumor   - - ++ + 0 0 0.0927
 Metastatic tumor   - - - - 0 0 0
1st 5        
 Implanted tumor   − (0/5) − (0/5) + (5/5) − (0/5) 0 0 0.1997
 Metastatic tumor   − (0/5) − (0/5) − (5/5) − (0/5) 0 0 0
2nd ~ 10th 45        
 Implanted tumor   − (0/45) − (0/45) − (0/45) − (0/45) 0 0 0
 Metastatic tumor   − (0/42) − (0/42) − (0/42) − (0/42) 0 0 0
  1. aMolecular analysis of the implanted and metastatic tumors revealed no detectable expression of CK8/18, E-cadherin, VCAM-1 and ICAM-1, except positive staining for VCAM-1 in the implanted tumor tissues of the first generation