Cancer risk in East Asian patients associated with acquired haemolytic anaemia: a nationwide population-based cohort study

Table 4 Sensitivity analysis showing varying estimates of the adjusted risk of developing subsequent cancer utilizing a Cox model by different cut-offs in lengthening the time lag for follow-up

	Comparison cohort			AHA cohort			Crude HR (95 % CI)	Adjusted HR (95 % CI)
Variable	Event	PYs	rate	Event	PYs	rate	Crude HR (95 % CI)	Adjusted HR (95 % CI)
Time lag (year)
> 1	961	206171	46.6	138	17765	77.7	1.70(1.42–2.04)	1.69(1.39–2.05)
> 2	771	200747	38.4	106	17131	61.9	1.67(1.36–2.04)	1.68(1.35–2.10)
> 3	610	187711	32.5	82	15680	52.3	1.66(1.32–2.09)	1.70(1.32–2.19)
> 4	433	170395	25.4	61	13926	43.8	1.78(1.36–2.33)	1.75(1.30–2.36)

Model adjusted for age, sex, urbanization of residency, DM, SLE, alcohol-use disorders, splenomegaly, CKD, liver cirrhosis, HBV, HCV and RA
Abbreviations: AHA acquired haemolytic anaemia, CI confidence interval, HR hazard ratio, PYs person-years, rate incidence rate, per 10,000 person-years

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