Table 1 Patients’ characteristics at baseline (N = 51)
Patients’ characteristics | Median | % |
|---|---|---|
Median age, years (range) | 57 (27–78) | |
Sex | ||
Male | 36 | 70.6 |
Female | 15 | 29.4 |
ECOG score | ||
0-1 | 48 | 94.1 |
2 | 3 | 5.9 |
Primary tumor site | ||
stomach | 33 | 64.7 |
Gastroesophageal junction | 18 | 35.3 |
Type of gastric cancer(assessed by central laboratory) | ||
Intestinal type | 34 | 66.7 |
Diffuse type | 10 | 19.6 |
Mix type | 7 | 13.7 |
HER2 status | ||
IHC 3+ | 38 | 74.5 |
IHC 2+,Dual SISH + | 13 | 25.5 |
HER2/CEP17 ratio by dc-SISH | ||
2.01–5.0 | 15 | 29.4 |
5.1–50 | 32 | 62.7 |
Failed | 4 | 7.8 |
Histology | ||
Well-moderately differentiated | 24 | 47.1 |
Poorly differentiated (signet ring cell, undetermined) | 27 | 52.9 |
Extent of disease | ||
Locally advanced | 7 | 13.7 |
Metastatic | 44 | 86.3 |
Metastastic disease | ||
Liver | 31 | 60.8 |
Lung | 13 | 25.5 |
Bone | 2 | 3.9 |
Ovarian | 1 | 1.9 |
Lymphnodes | 44 | 86.3 |
Prior gastrectomy | ||
No | 45 | 88.2 |
Yes | 6 | 11.8 |
Prior adjuvant chemotherapy | ||
No | 50 | 98.1 |
Yes | 1 | 1.9 |