Table 3 Univariate and multivariable analysis of OS and RFS in oropharyngeal and non-oropharyngeal patients

Oropharyngeal patients (n = 76)^a

 Age (continuous)

1.07 (1.01-1.12)

0.03

1.03 (0.97-1.10)

0.3

1.05 (1.00-1.10)

0.08

1.02 (0.97-1.08)

0.4

 Sex (males vs females)

 ECOG PS (0 vs 1–2)

4.08 (1.38-12.12)

<0.01

4.36 (1.18-16.06)

0.03

3.33 (1.24-8.89)

0.01

2.92 (0.95-8.97)

0.07

 Smoking status

<0.01

0.2

0.03

0.3

 (current smoker^b vs non-smoker)

0.17 (0.04-0.70)

0.34 (0.07-1.64)

0.31 (0.01-0.98)

0.53 (0.15-1.88)

 (current smoker^b vs ex-smoker)

0.22 (0.07-0.80)

0.28 (0.07-1.09)

0.28 (0.09-0.85)

0.40 (0.12-1.31)

 AJCC stage (I-II vs III-IV)

0.78 (0.26-2.34)

0.7

-

0.82 (0.31-2.19)

0.7

-

 Treatment (CRT and CRT + surgery vs RT and RT + surgery)

0.50 (0.46-4.93)

0.5

-

0.63 (0.32-4.00)

0.6

-

 NLR (≤5 vs > 5)

4.96 (1.66-14.80)

<0.01

4.60 (1.26-16.80)

0.02

3.50 (1.38-8.90)

<0.01

3.01 (1.07-8.45)

0.04

Non-oropharyngeal patients (n = 69)^c

 Age (continuous)

1.02 (0.99-1.06)

0.8

-

1.01 (0.98-1.032)

0.9

-

 Sex (males vs females)

1.05 (0.38-2.87)

0.9

-

0.81 (0.33-1.96)

0.6

-

 ECOG PS (0 vs 1–2)

3.37 (1.36-8.37)

<0.01

2.57 (0.98-6.76)

0.04

1.66 (0.82-3.36)

0.2

1.49 (0.70-3.21)

0.2

 Smoking status

0.04

<0.001

0.02

<0.001

 (current smoker^b vs non-smoker)

0.18 (0.04-0.79)

0.16 (0.03-0.76)

0.35 (0.14-0.87)

0.35 (0.14-0.90)

 (current smoker^b vs ex-smoker)

0.56 (0.22-1.44)

0.34 (0.12-0.94)

0.38 (0.16-0.90)

0.32 (0.13-0.79)

 AJCC stage (I-II vs III-IV)

1.43 (0.56-3.70)

0.5

-

1.53 (0.68-3.42)

0.3

-

 Treatment (CRT and CRT + surgery vs RT and RT + surgery)

0.85 (0.46-2.57)

0.8

-

1.01 (0.50-2.05)

1

-

 NLR (≤5 vs > 5)

3.32 (1.36-8.10)

<0.01

3.64 (1.34-9.87)

0.02

1.76 (0.79-3.96)

0.2

2.02 (0.83-4.91)

0.1