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Table 3 Distribution of MLH1, MGMT, DAPK-1 methylation according to tumor site and pathological characteristics

From: Gene methylation profile of gastric cancerous tissue according to tumor site in the stomach

  MLH1 M/U MGMT M/U DAPK-1 M/U
Tumor histological parameters Stomach upper-third cancerous tissue Stomach middle-third cancerous tissue Stomach lower-third cancerous tissue Stomach upper-third cancerous tissue Stomach middle-third cancerous tissue Stomach lower-third cancerous tissue Stomach upper-third cancerous tissue Stomach middle-third cancerous tissue Stomach lower-third cancerous tissue
Intestinal type 0/3 6/16 7/10 1/2 5/17 8/11 3/0 12/10 10/7
Diffuse type 1/5 3/14 8/8 1/5 7/10 11/5 1/5 7/10 7/9
p value 0.45 0.48 0.61 0.57 0.22 0.21 0.02 0.41 0.39
T1 0/1 1/2 2/4 0/1 1/2 4/2 1/0 2/1 4/2
T2 0/2 2/2 2/3 0/2 1/3 3/2 1/1 0/4 3/2
T3 0/2 5/11 8/9 1/1 4/12 10/7 1/1 6/10 7/10
T4 1/3 1/15 3/2 1/3 6/10 2/3 1/3 11/5 3/2
p value 0.7 0.17 0.83 0.62 0.88 0.84 0.59 0.06 0.67
N0 0/4 5/9 6/4 2/2 4/10 5/5 3/1 4/10 6/4
N1 0/2 2/4 3/5 0/2 2/4 5/3 0/2 2/4 4/4
N2 0/2 1/6 3/2 0/2 1/6 3/2 1/1 2/5 1/4
N3 1/0 1/11 3/7 0/1 5/7 6/4 0/1 11/1 6/4
p value 0.29 0.33 0.48 0.36 0.66 0.95 0.27 0.01 0.46
  1. M methylated allele, U unmethylated allele