Table 4 Association values between genotypes and metabolizer phenotypes
Association values between genotypes and the slow metabolizer phenotype using dominant, recessive and additive models | |||||
|---|---|---|---|---|---|
Gene | Polymorphism | Model | OR (95 % CI) | P-Value | Pc Value |
MTHFR | rs1801133 | Dominant (C/C vs. C/T + T/T) | C/T + T/T = 0.64 (0.42–0.99)* | 0.011 | 0.028** |
C/C = 3.11 (1.26–7.68)* | |||||
DRD3 | rs6280 | Recessive (C/C + C/T vs. T/T) | C/C + C/T = 0.62 (0.38–1.00) | 0.015 | 0.034** |
T /T = 2.63 (1.21–5.70)* | |||||
GSTM3 | rs1799735 | Additive (*A/*A vs. *A/*B) | *A/*A = 0.88 (0.70–1.09) | 0.126 | 0.308 |
*A/*B = 3.50 (0.64–19.20) | |||||
TNF | rs1800629 | Additive (G/G vs. G/A) | G/G = 0.89 (0.68–1.16) | 0.324 | 0.553 |
G/A = 1.82 (0.55–6.00) | |||||
MDR1 | rs1045642 | Dominant (C/C vs. C/T + T/T) | C/T + T/T = 1.45 (1.18–1.77)* | 0.008 | 0.020** |
C/C = 0.06 (0.003–1.00) | |||||
SLCO1B1 | rs4149056 | Recessive (C/C + C/T vs. T/T) | C/C + C/T = 1.33 (0.45–3.99) | 0.610 | 0.884 |
T/T = 0.93 (0.70–1.23) | |||||