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Table 2 IC50 values for inhibition of proliferation and migration/invasion by FRAX597, and of proliferation by gemcitabine

From: FRAX597, a PAK1 inhibitor, synergistically reduces pancreatic cancer growth when combined with gemcitabine

  FRAX IC50 proliferation (μM) FRAX IC50 migration/invasion (nM) Gemcitabine IC50 proliferation (nM)
PANC-1 2.0 ± 0.2 290 ± 70 33 ± 3
MiaPaCa-2 1.4 ± 0.4 105 ± 10 30 ± 3
BxPC-3 0.65 ± 0.1 330 ± 45 5 ± 1
Pan02 1.4 ± 0.1 605 ± 80 80 ± 10
LM-P 1.1 ± 0.2 150 ± 25 16 ± 2
  1. IC50 values were obtained by fitting the data in Fig. 3 and Additional file 2: Figure S2 using Sigmaplot