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Table 2 IC50 values for inhibition of proliferation and migration/invasion by FRAX597, and of proliferation by gemcitabine

From: FRAX597, a PAK1 inhibitor, synergistically reduces pancreatic cancer growth when combined with gemcitabine

 

FRAX IC50 proliferation (μM)

FRAX IC50 migration/invasion (nM)

Gemcitabine IC50 proliferation (nM)

PANC-1

2.0 ± 0.2

290 ± 70

33 ± 3

MiaPaCa-2

1.4 ± 0.4

105 ± 10

30 ± 3

BxPC-3

0.65 ± 0.1

330 ± 45

5 ± 1

Pan02

1.4 ± 0.1

605 ± 80

80 ± 10

LM-P

1.1 ± 0.2

150 ± 25

16 ± 2

  1. IC50 values were obtained by fitting the data in Fig. 3 and Additional file 2: Figure S2 using Sigmaplot
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BMC Cancer

ISSN: 1471-2407

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