OS | RFS | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Univariate analysis | Multivariate analysisa | Univariate analysis | Multivariate analysisa | |||||||||
Variables | HR | 95 % CI | p | HR | 95 % CI | p | HR | 95 % CI | p | HR | 95 % CI | p |
Age | 1.50 | 1.01–2.89 | 0.092 | 1.12 | 0.62–2.36 | 0.147 | ||||||
(≤65 vs. > 65) | ||||||||||||
Sex | 1.09 | 0.61–1.79 | 0.671 | 0.86 | 0.43–1.58 | 0.704 | ||||||
(female vs. male) | ||||||||||||
Tobacco use | 1.26 | 1.17–3.08 | 0.143 | 1.03 | 0.52–1.97 | 0.766 | ||||||
(no vs. yes) | ||||||||||||
TNM stage | 3.25 | 1.66–5.91 | 0.0007 | 2.02 | 0.93–4.37 | 0.012 | 3.08 | 1.49–6.24 | 0.0009 | 2.27 | 1.09–5.45 | 0.010 |
(I vs. II–III) | ||||||||||||
pT status | 1.65 | 0.88–2.89 | 0.070 | 1.22 | 0.57–2.39 | 0.198 | ||||||
(T1 vs. T2-4) | ||||||||||||
pN status | 4.19 | 2.10–7.72 | 0.0005 | 2.34 | 1.02–5.99 | 0.005 | 3.55 | 1.71–7.23 | 0.0004 | 2.76 | 1.46–5.89 | 0.003 |
(N0 vs. N1-2) | ||||||||||||
Pleural involvement | 0.77 | 0.31–1.52 | 0.830 | 0.67 | 0.39–1.43 | 0.902 | ||||||
(no vs. yes) | ||||||||||||
Differentiation (well/moderate vs. poor) | 1.32 | 0.72–2.61 | 0.127 | 1.07 | 0.51–1.91 | 0.722 | ||||||
Foxc2 expression | 1.98 | 0.75–3.92 | 0.036 | 1.90 | 0.76–4.05 | 0.039 | 2.13 | 1.08–4.15 | 0.011 | 1.54 | 0.89–3.67 | 0.077 |
(low vs. high) | ||||||||||||
E-cadherin expression | 2.03 | 0.97–4.12 | 0.024 | 1.77 | 0.79–3.78 | 0.098 | 2.09 | 1.12–4.37 | 0.043 | 1.38 | 0.65–2.99 | 0.092 |
(preserved vs. impaired) | ||||||||||||
Foxc2/E-cadherin expression | ||||||||||||
1 vs. 2 | 1.45 | 0.63–2.80 | 0.117 | 1.35 | 0.76–2.55 | 0.122 | ||||||
1 vs. 3 | 1.70 | 0.88–3.23 | 0.062 | 1.47 | 0.71–2.68 | 0.103 | ||||||
1 vs. 4 | 3.04 | 1.23–5.75 | 0.0009 | 2.41 | 1.12–4.67 | 0.002 | 2.55 | 1.29–5.16 | 0.008 | 2.06 | 0.87–4.17 | 0.035 |
1 vs. 2 + 3 + 4 | 1.85 | 0.90–3.53 | 0.026 | 1.34 | 0.64–2.23 | 0.168 | 1.56 | 0.74–3.05 | 0.071 |