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Table 3 Univariate and multivariate analysis of factors associated with OS and RFS of 309 NSCLCs

From: Prognostic value of high FoxC2 expression in resectable non-small cell lung cancer, alone or in combination with E-cadherin expression

  OS RFS
Univariate analysis Multivariate analysisa Univariate analysis Multivariate analysisa
Variables HR 95 % CI p HR 95 % CI p HR 95 % CI p HR 95 % CI p
Age 1.50 1.01–2.89 0.092     1.12 0.62–2.36 0.147    
(≤65 vs. > 65)
Sex 1.09 0.61–1.79 0.671     0.86 0.43–1.58 0.704    
(female vs. male)
Tobacco use 1.26 1.17–3.08 0.143     1.03 0.52–1.97 0.766    
(no vs. yes)
TNM stage 3.25 1.66–5.91 0.0007 2.02 0.93–4.37 0.012 3.08 1.49–6.24 0.0009 2.27 1.09–5.45 0.010
(I vs. II–III)
pT status 1.65 0.88–2.89 0.070     1.22 0.57–2.39 0.198    
(T1 vs. T2-4)
pN status 4.19 2.10–7.72 0.0005 2.34 1.02–5.99 0.005 3.55 1.71–7.23 0.0004 2.76 1.46–5.89 0.003
(N0 vs. N1-2)
Pleural involvement 0.77 0.31–1.52 0.830     0.67 0.39–1.43 0.902    
(no vs. yes)
Differentiation (well/moderate vs. poor) 1.32 0.72–2.61 0.127     1.07 0.51–1.91 0.722    
Foxc2 expression 1.98 0.75–3.92 0.036 1.90 0.76–4.05 0.039 2.13 1.08–4.15 0.011 1.54 0.89–3.67 0.077
(low vs. high)
E-cadherin expression 2.03 0.97–4.12 0.024 1.77 0.79–3.78 0.098 2.09 1.12–4.37 0.043 1.38 0.65–2.99 0.092
(preserved vs. impaired)             
Foxc2/E-cadherin expression
1 vs. 2 1.45 0.63–2.80 0.117     1.35 0.76–2.55 0.122    
1 vs. 3 1.70 0.88–3.23 0.062     1.47 0.71–2.68 0.103    
1 vs. 4 3.04 1.23–5.75 0.0009 2.41 1.12–4.67 0.002 2.55 1.29–5.16 0.008 2.06 0.87–4.17 0.035
1 vs. 2 + 3 + 4 1.85 0.90–3.53 0.026 1.34 0.64–2.23 0.168 1.56 0.74–3.05 0.071    
  1. OS overall survival; RFS recurrence-free survival
  2. aVariables were adopted for their prognostic significance by univariate analysis