Fig. 3
From: Anti-Hu Antibody Associated Paraneoplastic Cerebellar Degeneration in Head and Neck Cancer
Immunohistochemistry on Rat Cerebellum and Primary Tumor Biopsy. Anti-Hu antibodies in the patient’s serum show an intensive labeling of nuclei and cytoplasm of brain stem neurons (arrowheads) (a). Serum of a healthy individual remains negative (b). Biopsy of the primary tumor reveals strong expression of Hu-antigen in the majority of tumor cells (c; biotinylated anti-Hu IgG). Staining with a biotinylated control IgG remains negative (d). Magnification: x400