Table 1 Summary of expression and function of SLIT1, SLIT2, SLIT3, ROBO1, ROBO2 and ROBO4 in cancers
From: The emerging role of Slit-Robo pathway in gastric and other gastro intestinal cancers
Gene | Expression in cancers | Function | Metastasis | References | |
|---|---|---|---|---|---|
SLIT1 | Upregulation | Prostate cancer | Increased expression in prostate tumors | Â | [97] |
SLIT2 | Downregulation | Colorectal cancer | Tumour suppress | Suppress | |
Esophageal squamous cell carcinoma | Correlated with poor overall survival | Suppress | [84] | ||
Intestinal tumors | Promotes intestinal tumorigenesis | Â | [88] | ||
Breast cancer | Tumour suppressor and low expression is associated with poor survival and increased metastasis | Suppress | |||
Lung cancer | Tumour suppressor | Suppress | |||
Advanced gastric cancer | Knockdown of SLIT2 in gastric cancer cells promotes cell growth and metastasis in vitro and in vivo | Suppress | |||
Upregulation | Colorectal cancer | Induce malignant transformation of colorectal epithelial cell and tumor metastasis | Promote | ||
SLIT3 | Downregulation | Colorectal cancer | SLIT3 is frequently methylated in colorectal cancers | Â | |
Breast cancer | SLIT3 methylation in breast tumours correlated with reduced SLIT3 expression | Â | [10] | ||
Liver cancer | SLIT3 was significantly down-regulated in cell lines with high-AFP background | Â | [75] | ||
ROBO1 | Downregulation | Breast cancer | A high frequency of allele loss | Â | |
Lung cancer | A high frequency of allele loss | Â | [69] | ||
Prostate cancer | ROBO1 expression was significantly reduced in prostate tumors | Â | [97] | ||
Upregulation | Gastric cancer | SLIT2 interacted with ROBO1 to promote gastric cancer invasion | Promote | ||
Liver cancer | Overexpressed in and shed into serum for prediction of tumor stage and differentiation status | Â | |||
Intestinal tumors | Promotes intestinal tumorigenesis | Promote | [88] | ||
Pancreatic cancer | Contribute to the lymphatic metastasis of pancreatic cancer | Promote | [86] | ||
Colorectal cancer | ROBO1 was significantly associated with an increased metastatic risk and poorer overall survival in colorectal carcinoma patients | Promote | [77] | ||
ROBO2 | Upregulation | Liver cancer | ROBO2 were significantly up-regulated cell lines with high-AFP background | Â | [75] |
ROBO4 | Downregulation | Liver cancer | ROBO4 could discriminate poorly differentiated HCC from other subgroups | Â | [75] |