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Table 2 Univariable survival analysis of TSR and other prognostic factors

From: The prognostic significance of tumour-stroma ratio in endometrial carcinoma

  Overall survival Disease-free survival
Factor HR (95 % CI) P HR (95 % CI) P
LogTSR (continuous) 1.75 (1.04–2.94) 0.034 1.61 (0.98–2.64) 0.058
TSR ( ≥1.30 vs. <1.30) 2.51 (1.22–5.14) 0.012 2.18 (1.15–4.16) 0.017
Age (continuous) 1.07 (1.05–1.09) <0.001 1.06 (1.05–1.08) <0.001
Stage (FIGO 2009)     
 I Referent Referent Referent Referent
 II 1.83 (1.00–3.36) 0.051 1.69 (0.94–3.01) 0.078
 III 3.21 (2.10–4.90) <0.001 2.93 (1.96–4.39) <0.001
 IV 11.44 (6.72–19.32) <0.001 9.15 (5.52–15.15) <0.001
Grade     
 1 Referent Referent Referent Referent
 2 1.61 (0.95–2.75) 0.080 1.53 (0.93–2.49) 0.092
 3 3.49 (2.22–5.49) <0.001 2.95 (1.94–4.48) <0.001
Lymphovascular invasion (yes vs. no) 3.00 (2.04–4.42) <0.001 2.81 (1.95–4.04) <0.001
  1. Univariable Cox proportional hazards regression for overall and disease-free survival. TSR was analysed both as a continuous variable (logTSR) and dichotomised according to the optimised cut-off
  2. Abbreviations: CI confidence interval, FIGO international federation of gynaecology and obstetrics, HR hazard ratio, TSR tumour-stroma ratio