Fig. 5

Comparison of local tumor growth and distant metastasis in CB17.Scid mice. PC3-mCD47 and PC3-GFP-Luc cells were implanted subcutaneously to the right flank of CB17.Scid mice. Tumor growth was measured periodically for four weeks (a) before the tumors were excised. Then the animals were imaged weekly for bioluminescent signal (b) for six weeks before they were euthanized for collection of lungs and livers. Shown on the right-hand side of B are typical images from each animal group. Metastatic lesions in the lung and liver were determined by microscopic examination of H&E stained tissue sections (c). ✱p < 0.05 as compared to PC3-GFP-Luc