Author | Phase | Race | Jadad score | Group | Regimen | N | Eligible for evaluation | Male (%) | Median age | PS 0-1(%) | Stage IV(%) | Histology Ad. (%) | Median cycles |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Negoro S et al.[13] 2003 | III | Japanese | 5 | IP | P: 80mg/m2 day 1, I: 60mg/m2, day 1, 8, 15, q 28days | 133 | 129 | 76 | 64 | 94 | 62 | 60 | 3 |
PV | P: 80mg/m2 d1, V: 3mg/m2, day 1, 8, 15, q 28days | 133 | 122 | 80 | 64 | 94 | 63 | 60 | 2 | ||||
Yamamoto N et al.[14] 2004 | II | Japanese | 5 | DI | D: 60mg/m2 day 8, I: 60mg/m2, day 1, 8, q 21days | 57 | 57 | 67 | 60 | 100 | 75 | 77 | 2 |
DP | P: 80mg/m2 day 1, D: 60mg/m2, day 1, q 21days | 51 | 51 | 73 | 62 | 100 | 78 | 71 | 2 | ||||
Ohe Y et al.[15] 2007 | III | Japanese | 5 | IP | P: 80mg/m2 day 1, I: 60mg/m2, day 1, 8, 15, q 28days | 151 | 145 | 67 | 62 | 100 | 79 | 83 | 3 |
TC | T: 200mg/m2 day 1, C: AUC 6, day 1, q 21days | 150 | 145 | 68 | 63 | 100 | 81 | 72 | 3 | ||||
GP | P: 80mg/m2 day 1, G: 1000mg/m2, day 1, 8, q 21days | 151 | 146 | 70 | 61 | 100 | 79 | 74 | 3 | ||||
NP | P: 80mg/m2 day 1, N :20mg/m2 , day 1, 8, q 21days | 150 | 145 | 70 | 61 | 100 | 82 | 75 | 3 | ||||
Han JY et al.[16] 2008 | II | Korean | 5 | IP | P: 30mg/m2, I :65mg/m2, day 1, 8, q21days | 75 | 72 | 77 | 58 | 89 | 87 | 71 | 5 |
GN | G: 900mg/m2, N :25mg/m2 , day 1, 8, q 21days | 71 | 71 | 82 | 60 | 92 | 87 | 69 | 4 | ||||
Zhao WY et al.[17] 2012 | II | Chinese | 4 | IP | P: 25mg/m2 day 1–3, I :100mg/m2, day 1, 8, q 21days | 31 | 31 | 68 | 59* | 68 | 65 | 61 | 3 |
GP | P: 25mg/m2 day 1–3, G :1000mg/m2, day 1, 8, q 21days | 32 | 32 | 72 | 60* | 75 | 59 | 56 | 3 | ||||
Takiguchi Y et al.[18] 2000 | III | Japanese | 3 | IP | P: 80mg/m2 day 1, I: 60mg/m2 , day 1, 8, 15, q 28days | 104 | 98 | 75 | 62 | 94 | 59 | NR | NR |
PV | P: 80mg/m2 day 1, V: 3mg/m2 , day 1, 8, 15, q 28days | 106 | 101 | ||||||||||
Rocha Lima CM et al.[19] 2004 | II | American | 5 | GI | G :1000 mg/ m2 day 1, 8, I: 100 mg/m2, day 1, q 21 days | 39 | 36 | 72 | 63 | 100 | 77 | 46 | 4 |
GD | G: 1000mg/m2 day 1, 8, D: 40mg/m2, day 1,8, q 21days | 39 | 36 | 46 | 57 | 100 | 79 | 59 | 4 |