High EGFR protein expression and exon 9 PIK3CA mutations are independent prognostic factors in triple negative breast cancers

Jacot, William; Mollevi, Caroline; Fina, Frédéric; Lopez-Crapez, Evelyne; Martin, Pierre-Marie; Colombo, Pierre-Emmanuel; Bibeau, Frédéric; Romieu, Gilles; Lamy, Pierre-Jean

doi:10.1186/s12885-015-1977-3

Table 2 Correlations between EGFR amplification, EGFR protein level, PIK3CA mutation, PTEN status and clinicopathological characteristics

From: High EGFR protein expression and exon 9 PIK3CA mutations are independent prognostic factors in triple negative breast cancers

Patients’ characteristics	EGFR gene status									EGFR protein level							PIK3CA mutations							PTEN status
	Normal		Deletion		Amplifi-cation		Polysomy		p	Lower tercile		Middle tercile		Upper tercile		p	Exon 9		Exon 20		No		p	Deletion		No deletion		p
	N	%	N	%	N	%	N	%		N	%	N	%	N	%		N	%	N	%	N	%		N	%	N	%
Age								0.119							0.412							0.347					0.394
<55 years	76	49.3	6	54.5	11	61.1	5	25.0		31	48.4	27	43.5	35	55.6		5	35.7	6	35.3	87	50.3		23	53.5	72	45.9
≥55 years	78	50.7	5	45.5	7	38.9	15	75.0		33	51.6	35	56.5	28	44.4		9	64.3	11	64.7	86	49.7		20	46.5	85	54.1
T status								0.878							0.836							0.384					0.387
T1	63	40.9	4	36.4	9	50.0	8	40.0		25	39.1	25	40.3	28	44.4		8	57.1	8	47.1	68	39.3		15	34.9	67	42.7
T2+	91	59.1	7	63.6	9	50.0	12	60.0		39	60.9	37	59.7	35	55.6		6	42.9	9	52.9	105	60.7		28	65.1	90	57.3
N status								0.234							0.182							0.491					0.475
N0	103	66.9	6	54.5	8	44.4	14	70.0		47	73.4	36	58.1	40	63.5		11	78.6	10	58.8	111	64.2		30	69.8	99	63.0
N+	51	33.1	5	45.5	10	55.6	6	30.0		17	26.6	26	41.9	23	36.5		3	21.4	7	41.2	62	35.8		13	30.2	58	37.0
SBR-EE grade								0.466							0.871							0.038					<0.001
I-II	49	32.5	4	36.4	6	33.3	10	50.0		22	34.9	19	30.7	21	34.4		9	64.3	7	41.2	53	31.2		4	9.8	63	40.4
III	102	67.5	7	63.6	12	66.7	10	50.0		41	65.1	43	69.3	40	65.6		5	35.7	10	58.8	117	68.8		37	90.2	93	59.6
Histology								0.102							0.974							0.103					0.526
Ductal	119	77.3	11	100	17	94.4	15	75.0		50	78.1	50	80.7	50	79.4		12	85.7	10	58.8	141	81.5		36	83.7	123	78.3
Lobular and other	35	22.7	0	0.0	1	5.6	5	5.0		14	21.2	12	19.3	13	20.6		2	14.3	7	41.8	32	18.5		7	16.3	34	21.7
EGFR Gene Status									-						0.164							0.873					0.224
Normal	154	100	0	0.0	0	0.0	0	0.0		47	74.6	51	82.3	44	69.8		11	78.6	13	76.4	130	75.6		33	76.8	120	76.9
Deletion	0	0.0	11	100	0	0.0	0	0.0		3	4.8	3	4.8	3	4.8		0	0.0	2	11.8	9	5.2		0	0.0	11	7.0
Amplification	0	0.0	0	0.0	18	100	0	0.0		4	6.3	2	3.2	11	17.5		1	7.1	1	5.9	16	9.3		5	11.6	12	7.8
Polysomy	0	0.0	0	0.0	0	0.0	20	100		9	14.3	6	9.7	5	7.9		2	14.3	1	5.9	17	9.9		5	11.6	13	8.3
EGFR Protein level								0.164								-						0.180					0.110
Lower tercile	47	33.1	3	33.3	4	23.5	9	45.0		64	100	0	0.0	0	0.0		3	27.3	4	26.7	57	35.0		9	21.4	53	36.8
Middle tercile	51	35.9	3	33.3	2	11.8	6	30.0		0	0.0	62	100	0	0.0		7	63.6	4	26.7	51	31.3		14	33.3	47	32.6
Upper tercile	44	31.0	3	33.3	11	64.7	5	25.0		0	0.0	0	0.0	63	100		1	9.1	7	46.6	55	33.7		19	45.3	44	30.6
PIK3CA Mutations								0.873							0.180								-				0.565
Exon 9	11	7.1	0	0.0	1	5.6	2	10.0		3	4.7	7	11.3	1	1.60		14	100	0	0.0	0	0.0		1	2.3	12	7.6
Exon 20	13	8.4	2	18.2	1	5.6	1	5.0		4	6.2	4	6.4	7	11.1		0	0.0	17	100	0	0.0		3	7.0	12	7.6
No	130	84.5	9	81.8	16	88.8	17	85.0		57	89.1	51	82.3	55	87.3		0	0.0	0	0.0	173	100		39	90.7	133	84.8
PTEN Status								0.224							0.110							0.565						-
Deletion	33	21.6	0	0.0	5	29.4	5	27.8		9	14.5	14	23.0	19	30.2		1	7.7	3	20.0	39	22.7		43	100	0	0.0
No deletion	120	78.4	11	100	12	70.6	13	72.2		53	85.5	47	77.0	44	69.8		12	92.3	12	80.0	133	77.3		0	0.0	157	100

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ISSN: 1471-2407

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