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Table 2 Correlations between EGFR amplification, EGFR protein level, PIK3CA mutation, PTEN status and clinicopathological characteristics

From: High EGFR protein expression and exon 9 PIK3CA mutations are independent prognostic factors in triple negative breast cancers

Patients’ characteristics EGFR gene status EGFR protein level PIK3CA mutations PTEN status
  Normal Deletion Amplifi-cation Polysomy p Lower tercile Middle tercile Upper tercile p Exon 9 Exon 20 No p Deletion No deletion p
  N % N % N % N %   N % N % N %   N % N % N %   N % N %  
Age         0.119       0.412       0.347     0.394
 <55 years 76 49.3 6 54.5 11 61.1 5 25.0   31 48.4 27 43.5 35 55.6   5 35.7 6 35.3 87 50.3   23 53.5 72 45.9  
 ≥55 years 78 50.7 5 45.5 7 38.9 15 75.0   33 51.6 35 56.5 28 44.4   9 64.3 11 64.7 86 49.7   20 46.5 85 54.1  
T status         0.878       0.836       0.384     0.387
 T1 63 40.9 4 36.4 9 50.0 8 40.0   25 39.1 25 40.3 28 44.4   8 57.1 8 47.1 68 39.3   15 34.9 67 42.7  
 T2+ 91 59.1 7 63.6 9 50.0 12 60.0   39 60.9 37 59.7 35 55.6   6 42.9 9 52.9 105 60.7   28 65.1 90 57.3  
N status         0.234       0.182       0.491     0.475
 N0 103 66.9 6 54.5 8 44.4 14 70.0   47 73.4 36 58.1 40 63.5   11 78.6 10 58.8 111 64.2   30 69.8 99 63.0  
 N+ 51 33.1 5 45.5 10 55.6 6 30.0   17 26.6 26 41.9 23 36.5   3 21.4 7 41.2 62 35.8   13 30.2 58 37.0  
SBR-EE grade         0.466       0.871       0.038     <0.001
 I-II 49 32.5 4 36.4 6 33.3 10 50.0   22 34.9 19 30.7 21 34.4   9 64.3 7 41.2 53 31.2   4 9.8 63 40.4  
 III 102 67.5 7 63.6 12 66.7 10 50.0   41 65.1 43 69.3 40 65.6   5 35.7 10 58.8 117 68.8   37 90.2 93 59.6  
Histology         0.102       0.974       0.103     0.526
 Ductal 119 77.3 11 100 17 94.4 15 75.0   50 78.1 50 80.7 50 79.4   12 85.7 10 58.8 141 81.5   36 83.7 123 78.3  
 Lobular and other 35 22.7 0 0.0 1 5.6 5 5.0   14 21.2 12 19.3 13 20.6   2 14.3 7 41.8 32 18.5   7 16.3 34 21.7  
EGFR Gene Status          -       0.164       0.873     0.224
 Normal 154 100 0 0.0 0 0.0 0 0.0   47 74.6 51 82.3 44 69.8   11 78.6 13 76.4 130 75.6   33 76.8 120 76.9  
 Deletion 0 0.0 11 100 0 0.0 0 0.0   3 4.8 3 4.8 3 4.8   0 0.0 2 11.8 9 5.2   0 0.0 11 7.0  
 Amplification 0 0.0 0 0.0 18 100 0 0.0   4 6.3 2 3.2 11 17.5   1 7.1 1 5.9 16 9.3   5 11.6 12 7.8  
 Polysomy 0 0.0 0 0.0 0 0.0 20 100   9 14.3 6 9.7 5 7.9   2 14.3 1 5.9 17 9.9   5 11.6 13 8.3  
EGFR Protein level         0.164        -       0.180     0.110
 Lower tercile 47 33.1 3 33.3 4 23.5 9 45.0   64 100 0 0.0 0 0.0   3 27.3 4 26.7 57 35.0   9 21.4 53 36.8  
 Middle tercile 51 35.9 3 33.3 2 11.8 6 30.0   0 0.0 62 100 0 0.0   7 63.6 4 26.7 51 31.3   14 33.3 47 32.6  
 Upper tercile 44 31.0 3 33.3 11 64.7 5 25.0   0 0.0 0 0.0 63 100   1 9.1 7 46.6 55 33.7   19 45.3 44 30.6  
PIK3CA Mutations         0.873       0.180        -     0.565
 Exon 9 11 7.1 0 0.0 1 5.6 2 10.0   3 4.7 7 11.3 1 1.60   14 100 0 0.0 0 0.0   1 2.3 12 7.6  
 Exon 20 13 8.4 2 18.2 1 5.6 1 5.0   4 6.2 4 6.4 7 11.1   0 0.0 17 100 0 0.0   3 7.0 12 7.6  
 No 130 84.5 9 81.8 16 88.8 17 85.0   57 89.1 51 82.3 55 87.3   0 0.0 0 0.0 173 100   39 90.7 133 84.8  
PTEN Status         0.224       0.110       0.565      -
 Deletion 33 21.6 0 0.0 5 29.4 5 27.8   9 14.5 14 23.0 19 30.2   1 7.7 3 20.0 39 22.7   43 100 0 0.0  
 No deletion 120 78.4 11 100 12 70.6 13 72.2   53 85.5 47 77.0 44 69.8   12 92.3 12 80.0 133 77.3   0 0.0 157 100