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Table 1 Copy number variations of oncogenes and tumor suppressors in three NSCLC cell lines

From: The pan-HDAC inhibitor panobinostat acts as a sensitizer for erlotinib activity in EGFR-mutated and -wildtype non-small cell lung cancer cells

gene

ALK

BRAF

CDKN1A

EGFR

KRAS

MET

MYC

TP53

TP63

PI3K

HCC827

n

n

n

4

3

n

4

3

n

n

A549

n

n

1

3

3

n

3

n

1

n

NCI-H460

n

n

1

1

n

n

4

n

n

n

  1. Copy numbers of selected genes in HCC827, A549 and NCI-H460 were determined by Affymetrix SNP Array 6.0
  2. 0 = complete loss, 1 = 50 % loss, n = no loss or gain, 3 = 50 % gain and 4 = 100 % gain of genomic material, relative to ploidy (all percentages are approximate values computed with Affymetrix Genotyping Console Software)