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Table 1 Copy number variations of oncogenes and tumor suppressors in three NSCLC cell lines

From: The pan-HDAC inhibitor panobinostat acts as a sensitizer for erlotinib activity in EGFR-mutated and -wildtype non-small cell lung cancer cells

gene ALK BRAF CDKN1A EGFR KRAS MET MYC TP53 TP63 PI3K
HCC827 n n n 4 3 n 4 3 n n
A549 n n 1 3 3 n 3 n 1 n
NCI-H460 n n 1 1 n n 4 n n n
  1. Copy numbers of selected genes in HCC827, A549 and NCI-H460 were determined by Affymetrix SNP Array 6.0
  2. 0 = complete loss, 1 = 50 % loss, n = no loss or gain, 3 = 50 % gain and 4 = 100 % gain of genomic material, relative to ploidy (all percentages are approximate values computed with Affymetrix Genotyping Console Software)