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Table 3 Odds ratios (OR) and 95 % confidence intervals (CI) for the association of dietary calcium intake and colorectal cancer sub-sites

From: Dietary calcium intake and the risk of colorectal cancer: a case control study

  Control Proximal colon Distal colon Rectum
Total energy adjusted dietary calcium intake (mg/day) No No Age-adjusted OR(95 % CI) Multivariate ORa(95 % CI) No Age-adjusted OR(95 % CI) Multivariate OR(95 % CI) No Age-adjusted OR(95 % CI) Multivariate OR(95 % CI)
Men N = 1872 N = 113    N = 178    N = 320   
Q1 (<335) 468 26 1.00 1.00 60 1.00 1.00 109 1.00 1.00
Q2 (335 - < 432) 468 43 1.63(0.99–2.70) 1.40(0.83–2.37) 63 1.04(0.71–1.51) 0.90(0.60–1.34) 112 1.02(0.76–1.36) 0.85(0.61–1.17)
Q3 (432 - < 567) 468 28 1.04(0.60–1.80) 0.81(0.45–1.45) 41 0.66(0.43–1.00) 0.51(0.33–0.81) 71 0.63(0.45–0.87) 0.47(0.32–0.67)
Q4 (≥567) 468 16 0.58(0.31–1.10) 0.35(0.17–0.74) 14 0.22(0.12–0.40) 0.13(0.07–0.26)c 28 0.25(0.16–0.38) 0.13(0.08–0.23)c
P-value for trendb    0.021 <0.001   <0.001 <0.001   <0.001 <0.001
Women N = 894 N = 53    N = 113    N = 124   
Q1 (<380) 224 26 1.00 1.00 43 1.00 1.00 51 1.00 1.00
Q2 (380 - < 519) 223 18 0.70(0.37–1.32) 0.75(0.39–1.46) 48 1.12(0.72–1.76) 1.11(0.68–1.81) 43 0.85(0.54–1.33) 0.93(0.58–1.52)
Q3 (519 - < 663) 223 6 0.23(0.09–0.57) 0.27(0.11–0.72) 15 0.35(0.19–0.65) 0.35(0.18–0.68) 22 0.43(0.25–0.74) 0.55(0.31–0.99)
Q4 (≥663) 224 3 0.11(0.03–0.38) 0.13(0.03–0.48) 7 0.16(0.07–0.37) 0.12(0.05–0.32) 8 0.16(0.07–0.34) 0.20(0.09–0.47)
P-value for trend    <0.001 0.001   <0.001 <0.001   <0.001 <0.001
  1. aAdjusted by age, education level, regular exercise, fiber intake, calcium supplement use, and total energy intake
  2. bTest for trend calculated with the median intake for each category of dietary calcium intake as a continuous variable
  3. cThe odds ratio was statistically different from that of proximal colon (p = 0.05 for distal colon and p = 0.03 for rectum)