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Table 3 Odds ratios (OR) and 95 % confidence intervals (CI) for the association of dietary calcium intake and colorectal cancer sub-sites

From: Dietary calcium intake and the risk of colorectal cancer: a case control study

 

Control

Proximal colon

Distal colon

Rectum

Total energy adjusted dietary calcium intake (mg/day)

No

No

Age-adjusted OR(95 % CI)

Multivariate ORa(95 % CI)

No

Age-adjusted OR(95 % CI)

Multivariate OR(95 % CI)

No

Age-adjusted OR(95 % CI)

Multivariate OR(95 % CI)

Men

N = 1872

N = 113

  

N = 178

  

N = 320

  

Q1 (<335)

468

26

1.00

1.00

60

1.00

1.00

109

1.00

1.00

Q2 (335 - < 432)

468

43

1.63(0.99–2.70)

1.40(0.83–2.37)

63

1.04(0.71–1.51)

0.90(0.60–1.34)

112

1.02(0.76–1.36)

0.85(0.61–1.17)

Q3 (432 - < 567)

468

28

1.04(0.60–1.80)

0.81(0.45–1.45)

41

0.66(0.43–1.00)

0.51(0.33–0.81)

71

0.63(0.45–0.87)

0.47(0.32–0.67)

Q4 (≥567)

468

16

0.58(0.31–1.10)

0.35(0.17–0.74)

14

0.22(0.12–0.40)

0.13(0.07–0.26)c

28

0.25(0.16–0.38)

0.13(0.08–0.23)c

P-value for trendb

  

0.021

<0.001

 

<0.001

<0.001

 

<0.001

<0.001

Women

N = 894

N = 53

  

N = 113

  

N = 124

  

Q1 (<380)

224

26

1.00

1.00

43

1.00

1.00

51

1.00

1.00

Q2 (380 - < 519)

223

18

0.70(0.37–1.32)

0.75(0.39–1.46)

48

1.12(0.72–1.76)

1.11(0.68–1.81)

43

0.85(0.54–1.33)

0.93(0.58–1.52)

Q3 (519 - < 663)

223

6

0.23(0.09–0.57)

0.27(0.11–0.72)

15

0.35(0.19–0.65)

0.35(0.18–0.68)

22

0.43(0.25–0.74)

0.55(0.31–0.99)

Q4 (≥663)

224

3

0.11(0.03–0.38)

0.13(0.03–0.48)

7

0.16(0.07–0.37)

0.12(0.05–0.32)

8

0.16(0.07–0.34)

0.20(0.09–0.47)

P-value for trend

  

<0.001

0.001

 

<0.001

<0.001

 

<0.001

<0.001

  1. aAdjusted by age, education level, regular exercise, fiber intake, calcium supplement use, and total energy intake
  2. bTest for trend calculated with the median intake for each category of dietary calcium intake as a continuous variable
  3. cThe odds ratio was statistically different from that of proximal colon (p = 0.05 for distal colon and p = 0.03 for rectum)