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Table 5 Factors affecting blood leukocyte methylation of COX-2

From: Methylation status of COX-2 in blood leukocyte DNA and risk of gastric cancer in a high-risk Chinese population

Characteristics Total (n = 380) SG/mild CAG (n = 285) Post-GC (n = 95)
n OR (95 % CI)a n OR (95 % CI)a n OR (95 % CI)a
Age
  < 60 160 1.00 120 1.00 40 1.00
  > =60 220 1.55(1.02–2.36) 165 1.54(0.94–2.51) 55 1.77(0.71–4.39)
Gender
 Female 104 1.00 78 1.00 26 1.00
 Male 276 1.34(0.71–2.53) 207 1.57(0.74–3.31) 69 0.90(0.25–3.20)
Smoking
 Never 149 1.00 112 1.00 37 1.00
 Ever 230 0.99(0.56–1.73) 173 0.89(0.47–1.69) 57 1.21(0.37–3.98)
 Current 205 0.96(0.57–1.64) 155 0.84(0.46–1.54) 50 1.40(0.45–4.39)
Drinking
 Never 171 1.00 131 1.00 40 1.00
 Ever 202 0.70(0.43–1.16) 154 0.61(0.34–1.09) 48 1.02(0.35–3.00)
 Current 182 0.74(0.46–1.20) 138 0.64(0.37–1.11) 44 1.22(0.43–3.43)
H. pylori infection
 Never 121 1.00 110 1.00 11 1.00
 Ever 259 0.54(0.34–0.88) 175 0.49(0.29–0.83) 84 1.18(0.28–4.98)
 Current 210 0.71(0.47–1.09) 150 0.69(0.43–1.12) 60 0.77(0.31–1.93)
  1. a Unconditional logistic regression analysis, adjusted for other factors (age, gender, smoking, drinking or H. pylori infection status)