Table 5 Factors affecting blood leukocyte methylation of COX-2
Characteristics | Total (n = 380) | SG/mild CAG (n = 285) | Post-GC (n = 95) | |||
|---|---|---|---|---|---|---|
n | OR (95 % CI)a | n | OR (95 % CI)a | n | OR (95 % CI)a | |
Age | ||||||
  < 60 | 160 | 1.00 | 120 | 1.00 | 40 | 1.00 |
  > =60 | 220 | 1.55(1.02–2.36) | 165 | 1.54(0.94–2.51) | 55 | 1.77(0.71–4.39) |
Gender | ||||||
 Female | 104 | 1.00 | 78 | 1.00 | 26 | 1.00 |
 Male | 276 | 1.34(0.71–2.53) | 207 | 1.57(0.74–3.31) | 69 | 0.90(0.25–3.20) |
Smoking | ||||||
 Never | 149 | 1.00 | 112 | 1.00 | 37 | 1.00 |
 Ever | 230 | 0.99(0.56–1.73) | 173 | 0.89(0.47–1.69) | 57 | 1.21(0.37–3.98) |
 Current | 205 | 0.96(0.57–1.64) | 155 | 0.84(0.46–1.54) | 50 | 1.40(0.45–4.39) |
Drinking | ||||||
 Never | 171 | 1.00 | 131 | 1.00 | 40 | 1.00 |
 Ever | 202 | 0.70(0.43–1.16) | 154 | 0.61(0.34–1.09) | 48 | 1.02(0.35–3.00) |
 Current | 182 | 0.74(0.46–1.20) | 138 | 0.64(0.37–1.11) | 44 | 1.22(0.43–3.43) |
H. pylori infection | ||||||
 Never | 121 | 1.00 | 110 | 1.00 | 11 | 1.00 |
 Ever | 259 | 0.54(0.34–0.88) | 175 | 0.49(0.29–0.83) | 84 | 1.18(0.28–4.98) |
 Current | 210 | 0.71(0.47–1.09) | 150 | 0.69(0.43–1.12) | 60 | 0.77(0.31–1.93) |