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Table 2 The temporal trends of COX-2 methylation levels during GC development

From: Methylation status of COX-2 in blood leukocyte DNA and risk of gastric cancer in a high-risk Chinese population

  n Methylation proportion P a
Median % (interquartile range)
Total pre-GC and post-GC samples
Pre-GC 74 2.5(1.5–4.4)  
Post-GC 95 2.3(1.2–3.9)  
P b   0.32  
Temporal trend
5–10 years pre-GC 32 1.9(1.4–4.0) 0.53
1–4 years pre-GC 42 3.0(2.0–4.5) 0.01
GC diag. year 46 2.2(1.1–2.8) Ref.
1–4 years post-GC 21 1.9(1.4–2.9) 0.80
5–10 years post-GC 28 2.8(1.8–4.9) 0.06
P trend c   0.32  
  1. aMann-Whitney Test/Wilcoxon Test
  2. b Unconditional logistic regression analysis, adjusted for age, gender, smoking, drinking and H. pylori infection status
  3. c Unconditional logistic regression analysis