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Fig. 5 | BMC Cancer

Fig. 5

From: RUNX1-Evi-1 fusion gene inhibited differentiation and apoptosis in myelopoiesis: an in vivo study

Fig. 5

DEGs involved in JNK pathway in Tg(RE:HSE:EGFP). Using Agilent microarray analysis, compared with WT at 3dpf, it showed that RUNX1-Evi-1 could down-regulate some crucial genes in JNK pathway, including c-JUN, ATF-2, Elk-1, and GADD153. MKK7 is a functional gene in MAPK pathway, which was also down-regulated in this model. The signaling pathways were analyzed and summarized by NIH-DAVID software (in KEGG) and the differentially expressed genes were marked with red star in the automatically generated figure. Western blot was further confirmed that JNK and cleaved p-JNK expression were inhibited in Tg(RE:HSE:EGFP) F2 generation

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