Fig. 4

Single-sample gene set enrichment analysis (ssGSEA). ssGSEA was performed for all 8 transcriptome libraries using fold changes in expression of each gene (ATC expression/average expression in 58 normal libraries) in order to identify enriched oncogenic signatures. Top 20 % most enriched signatures that were shared in two or more libraries are plotted. The molecular signatures enriched with up- and down-regulated ATC genes included genes that were up- and down-regulated upon knockdown of BMI1 or PCGF2 or both genes [26]. Standard names of the oncogenic signature gene sets from the MSigDB are listed below the plot