Fig. 2
From: Gonadotropin-mediated chemoresistance: Delineation of molecular pathways and targets
hCG and TLR ligands synergistically enhance chemo-resistance. a Cell viability analysis on COLO-205 cells incubated with hCG (for 24 h), individual TLR ligands (for 24 h) and curcumin (for 24 h) alone and in combination. H: hCG; P: Pam3CSK4; HK: HKLM; PI: Poly I:C; L: LPS; FL: Flagellin; F: FSL-1; I: Imiquimod; ss: ssRNA40; O: ODN2006. Means ± SEM of three independent experiments (with three replicates) are shown. In each case, data has been individually normalized to control cultures. (@p < 0.01 vs control cells, *p < 0.03 vs cells + curcumin, #p < 0.04, %p < 0.02, ^p < 0.0005, &p < 0.008 vs hCG + curcumin). b Western blot analysis of the phosphorylation of JNK (left panel) and ERK (right panel) in COLO-205 cells exposed hCG, individual TLR ligands and curcumin, individually or in combination, as indicated, in the manner described above