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Table 1 Genetics training, referrals and VUS knowledge by breast cancer specialists

From: Understanding of BRCA VUS genetic results by breast cancer specialists

  Total Medical oncologist Clinical oncologist Surgeon
No. (%) No. (%) No. (%) No. (%)
155 (100 %) 63 (40.7 %) 54 (34.8 %) 38 (24.5 %)
Genetics training     
 None 18 (11.6 %) 9 (14.3 %) 5 (9.3 %) 4 (10.5 %)
 Medical school/postgrad exams 115 (74.2 %) 47 (74.6 %) 44 (81.5 %) 24 (63.2 %)
 Genetics course 4 (3.6 %) 2 (3.2 %) 1 (1.9 %) 1 (2.6 %)
 Module with genetics service 1 (0.7 %) 0 (0 %) 1 (1.9 %) 0 (0 %)
 Specialist interest (no formal training) 9 (5.8 %) 2 (3.2 %) 1 (1.9 %) 6 (15.8 %)
 Higher degree 5 (3.2 %) 2 (3.2 %) 2 (3.7 %) 1 (2.6 %)
 Othera 3 (1.9 %) 1 (1.6 %) 0 (0 %) 2 (5.3 %)
Direct genetics service referral     
 Yes 143 (95.3 %) 59 (93.7 %) 49 (96.1 %) 35 (97.2 %)
 No 7 (4.7 %) 4 (6.4 %) 2 (3.9 %) 1 (2.8 %)
 Missing 5 (3.2 %) 0 (0 %) 3 (5.3 %) 2 (5.6 %)
Ability to interpret genetics report     
 Yes 45 (29.0 %) 14 (22.2 %) 13 (24.1 %) 18 (47.4 %)
 No 64 (41.3 %) 27 (42.9 %) 25 (46.3 %) 12 (31.6 %)
 Unsureb 46 (29.7 %) 22 (34.9 %) 16 (29.6 %) 8 (21.1 %)
VUS understanding     
 Fully understand 56 (36.1 %) 24 (38.1 %) 13 (24.1 %) 19 (50.0 %)
 Don't fully understand 66 (42.6 %) 25 (39.7 %) 24 (44.4 %) 17 (44.7 %)
 Not heard/don't understand 33 (21.3 %) 14 (22.2 %) 17 (31.5 %) 2 (5.3 %)
How common is a VUS?     
 <10 % 26 (21.1 %) 9 (17.0 %) 13 (31.0 %) 5 (15.2 %)
 10–20 % 61 (47.7 %) 29 (54.7 %) 15 (35.7 %) 17 (51.5 %)
 20–30 % 24 (18.8 %) 11 (20.8 %) 8 (19.1 %) 5 (15.2 %)
 30–40 % 11 (8.6 %) 4 (7.6 %) 3 (7.1 %) 4 (12.1 %)
 40–50 % 2 (1.6 %) 0 (0 %) 2 (4.8 %) 0 (0 %)
 >50 % 3 (2.3 %) 0 (0 %) 1 (2.4 %) 2 (6.1 %)
 Don't’ know/skipped Q 27 (17.4 %) 10 (15.9 %) 12 (22.2 %) 5 (13.2 %)
  1. a“Close cooperation with genetics over last 15 years – personal reading”, “Msc Module” “Experience in Genomics lab”
  2. bIf 2 answers were given (eg No/Unsure) this was interpreted as ‘Unsure’