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Table 3 Coexisting somatic mutations resulting in amino-acid changes identified using the Ion AmpliSeq Hotspot Panel version 2

From: Next-generation sequencing of tyrosine kinase inhibitor-resistant non-small-cell lung cancers in patients harboring epidermal growth factor-activating mutations

   Frequency (%)   Frequency (%)   Frequency (%)   Frequency (%)   Frequency (%)
Case 1 KIT M541L (COSM 28026) 70.9 TP53 P72R 53.2 --- --- --- --- --- ---
Case 2 PTEN L57W (COSM 5253) 21.2 --- --- --- --- --- --- --- ---
Case 3 TP53 P72R 57.0 CTNNB1 D32N (COSM 5672) 34.5 TP53 V73 del 29.1 CDH1 Q346* (COSM 19524) 25.1 --- ---
Case 4 TP53 P72R 60.3 TP53 R337C (COSM 11071) 18.0 --- --- --- --- --- ---
Case 5 TP53 P72R 46.9 KDR Q472H 46.9 KIT G534C 46.3 APC S1463fs 42.5 --- ---
Case 6 PDGFRA P567Q 100 TP53 V73W 72.6 TP53 P151S 57.5 KDR Q472H 42.4 ERBB4 C614Y 38.2
  SMAD4 R189H 29.0 PTEN R233Q 18.5 APC D1591N 18.4 HRAS T64* 17.9 AKT1 T21I 16.4
  KIT L647F 16.2 SKT11 D352N 15.1 PTEN H123Y (COSM 5078) 7.3 PTEN R130Q (COSM 5033) 7.2 --- ---
Case 7 TP53 P72R 96.7 SKT11 F345L 53.5 SKT11 P281L 53.3 KDR Q472H 42.6 --- ---
Case 8 TP53 P72R 98.4 KIT M541L (COSM 28026) 59.8 TP53 V154G (COSM 43903) 35.4 KDR Q472H 26.7 SMAD4 G423R 14.7
  ABL1 I347fs 11.1 ERBB4 C759T 8.8 FBXW7 M467I 8.0 MLH1 A169V 8.0 KDR G1284R 7.9
  APC P1433L 6.7 TP53 F338L 6.5 SMO P610S 6.4 MET D340A 5.8 NOTCH1 V1575M 5.7
  PTEN A328E 5.6 APC G1374K (COSM 18737) 5.1 MLH1 R148W 5.0 --- --- --- ---
Case 9 APC E1464fs 59.2 TP53 P72R 48.2 BRAF G442D 6.1 MET G1102D 5.5 SMO T223I 5.0
Case 10 MET N375K 55.7 TP53 P72R 42.0 CTNNB1 G34V 6.5 --- --- --- ---
Case 11 TP53 P72R 68.5 PTEN N329fs (COSM 4932) 39.5 TP53 K132R (COSM 11582) 29.7 --- --- --- ---
Case 12 TP53 P72R 98.1 KDR Q472H 96.4 TP53 V272fs 21.0 RB1 I682T 12.6 APC P1433L 9.6
  RET E884V 9.1 SMAD4 V354L 8.0 --- --- --- --- --- ---
Case 13 TP53 P72R 99.1 CDKN2 G155S 51.6 FLT3 W603* 45.2 KRAS E37K 33.3 SMO P641L 23.7
  IDH1 L103M 20.0 TP53 R267Q (COSM 43923) 18.8 GNA11 D205N 16.2 SMARCB1 P165S 14.0 RB1 M761T 13.9
  SMARCB1 V145L 12.4 TP53 G245R (COSM 10957) 10.8 NOTCH1 H1591T 10.7 ERBB4 G240V 10.0 KIT S715N 9.9
  FBXW7 R505H (COSM 25812) 9.8 FBXW7 M498I 9.2 MET S186L 8.8 IDH1 A111V 8.8 JAC3 V133I 8.5
  KIT V825I (COSM 19110) 8.1 TP53 G112S 6.5 TP53 K132E (COSM 10813) 6.3 HNF1A A193V 6.3 VHL K171T 5.7
  ALK P1191A 5.6 HNF1A T204I 5.3 --- --- --- --- --- ---
Case 14 PTEN H1047L 62.9 FGFR3 R765S 7.2 IDH1 P118L 5.7 --- --- --- ---
Case 15 TP53 P72R 100 MET A179M 5.1 --- --- --- --- --- ---