Table 1 Correlation of CD44s expression with demographics and histopathological findings in patients with ampullary adenocarcinoma who underwent resection
Extent of CD44s expressiona | |||
|---|---|---|---|
Negative or weak (< 25 %) | Moderate or dense (≥ 25 %) | P-value | |
Patients, number (%) | 55 (56 %) | 43 (44 %) | |
Age, y, mean (range) | 65 (32–90) | 65 (35–84) | 0.971 |
Sex | 0.839 | ||
Female | 26 (58 %) | 19 (42 %) | |
Male | 29 (55 %) | 24 (45 %) | |
Histology typeb | 0.139 | ||
Intestinal | 26 (54 %) | 22 (46 %) | |
Pancreaticobiliary | 19 (73 %) | 7 (27 %) | |
Gross tumor type | 0.059 | ||
Polypoid | 24 (45 %) | 29 (55 %) | |
Ulcerative | 17 (71 %) | 7 (29 %) | |
Mixed | 14 (67 %) | 7 (33 %) | |
Tumor size, cm | 2.1 (0.7–8.0) | 2.2 (0.8–5.5) | 0.625 |
Differentiationb | 0.904 | ||
Well | 26 (58 %) | 19 (42 %) | |
Moderate | 24 (59 %) | 17 (41 %) | |
Poor | 4 (50 %) | 4 (50 %) | |
Lymphovascular invasionb | 0.006 | ||
Negative | 13 (39 %) | 20 (61 %) | |
Positive | 24 (75 %) | 8 (25 %) | |
Perineural invasionb | 0.558 | ||
Negative | 19 (56 %) | 15 (44 %) | |
Positive | 12 (67 %) | 6 (33 %) | |
Resection margin | 0.167 | ||
Free | 48 (55 %) | 40 (45 %) | |
Microscopically positive | 7 (78 %) | 2 (22 %) | |
Macroscopically positive | 0 | 1 (100 %) | |
Pancreatic invasionb | 0.004 | ||
Negative | 19 (40 %) | 29 (60 %) | |
Positive | 34 (71 %) | 14 (29 %) | |
Tumor stage | 0.034 | ||
pT1 | 3 (33 %) | 6 (67 %) | |
pT2 | 17 (44 %) | 22 (56 %) | |
pT3 | 23 (68 %) | 11 (32 %) | |
pT4 | 12 (75 %) | 4 (25 %) | |
Lymph node metastasisb | 0.289 | ||
pN0 | 30 (52 %) | 28 (48 %) | |
pN1 | 23 (64 %) | 13 (36 %) | |
AJCC TNM stage | 0.019 | ||
Stage I | 16 (42 %) | 22 (58 %) | |
Stage II | 27 (64 %) | 15 (36 %) | |
Stage III | 12 (75 %) | 4 (25 %) | |
Stage IV | 0 | 2 (100 %) | |