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Table 1 Correlation of CD44s expression with demographics and histopathological findings in patients with ampullary adenocarcinoma who underwent resection

From: Dual role of CD44 isoforms in ampullary adenocarcinoma: CD44s predicts poor prognosis in early cancer and CD44ν is an indicator for recurrence in advanced cancer

  Extent of CD44s expressiona  
  Negative or weak (< 25 %) Moderate or dense (≥ 25 %) P-value
Patients, number (%) 55 (56 %) 43 (44 %)  
Age, y, mean (range) 65 (32–90) 65 (35–84) 0.971
Sex    0.839
 Female 26 (58 %) 19 (42 %)  
 Male 29 (55 %) 24 (45 %)  
Histology typeb    0.139
 Intestinal 26 (54 %) 22 (46 %)  
 Pancreaticobiliary 19 (73 %) 7 (27 %)  
Gross tumor type    0.059
 Polypoid 24 (45 %) 29 (55 %)  
 Ulcerative 17 (71 %) 7 (29 %)  
 Mixed 14 (67 %) 7 (33 %)  
Tumor size, cm 2.1 (0.7–8.0) 2.2 (0.8–5.5) 0.625
Differentiationb    0.904
 Well 26 (58 %) 19 (42 %)  
 Moderate 24 (59 %) 17 (41 %)  
 Poor 4 (50 %) 4 (50 %)  
Lymphovascular invasionb    0.006
 Negative 13 (39 %) 20 (61 %)  
 Positive 24 (75 %) 8 (25 %)  
Perineural invasionb    0.558
 Negative 19 (56 %) 15 (44 %)  
 Positive 12 (67 %) 6 (33 %)  
Resection margin    0.167
 Free 48 (55 %) 40 (45 %)  
 Microscopically positive 7 (78 %) 2 (22 %)  
 Macroscopically positive 0 1 (100 %)  
Pancreatic invasionb    0.004
 Negative 19 (40 %) 29 (60 %)  
 Positive 34 (71 %) 14 (29 %)  
Tumor stage    0.034
 pT1 3 (33 %) 6 (67 %)  
 pT2 17 (44 %) 22 (56 %)  
 pT3 23 (68 %) 11 (32 %)  
 pT4 12 (75 %) 4 (25 %)  
Lymph node metastasisb    0.289
 pN0 30 (52 %) 28 (48 %)  
 pN1 23 (64 %) 13 (36 %)  
AJCC TNM stage    0.019
 Stage I 16 (42 %) 22 (58 %)  
 Stage II 27 (64 %) 15 (36 %)  
 Stage III 12 (75 %) 4 (25 %)  
 Stage IV 0 2 (100 %)  
  1. Abbreviations: AJCC TNM stage, American Joint Committee on Cancer tumor, node, metastases staging system
  2. aAs determined by univariate analysis
  3. bExcluding patients without detailed recorded
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