|  |  |  | Meta-analysisa | Meta-regressionb | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|
 |  |  |  |  |  |  |  | Unadjusted | Adjusted for weighted mean age & period, & 10-year follow-up | ||
Treatment | Groups | DCIS cases | Local recurrence or death | Rate (%) & 95%CI | Model | P heterog | I2 heterogc | Rate (%) & 95 % CI | Rate (%) & 95 % CI | OR | P |
All local recurrence | Â | Â | Â | Â | Â | Â | Â | Â | Â | ||
Model P-value |  |  |  |  |  |  | P = 0.0002 | P = 0.0003 | P = 0.0003 |  | |
CS(alone) | 10 | 2038 | 541 | 25.9 | R | <0.001 | 85.5 | 24.9 | 25.1 | 3.12 | 0.001 |
 |  |  |  | 19.9–32.0 |  |  |  | 19.1–30.6 | 18.3–31.9 | 1.62–6.00 |  |
CS + TAM(no RT) | 1 | 567 | 112 | 19.8 | R | <0.001 | 86.7 | 19.7 | 24.7 | 3.05 | 0.024 |
 |  |  |  | 16.5-23.0 |  |  |  | 7.1–32.3 | 7.9–41.5 | 1.16–8.04 |  |
CS + RT(no TAM) | 11 | 4809 | 630 | 14.9 | R | <0.001 | 78.4 | 13.8 | 14.1 | 1.52 | 0.190 |
 |  |  |  | 11.8-18.0 |  |  |  | 10.6–16.9 | 10.3–17.8 | 0.81–2.86 |  |
CS + RT + TAM | 2 | 937 | 86 | 9.2 | F = R | ns | 53.6 | 8.5 | 9.7 | 1.00 |  |
 |  |  |  | 7.3-11.0 |  |  |  | 3.9–13.2 | 4.4–15.0 | - |  |
Total | 24 | 8351 | 1369 | Â | Â | Â | Â | Â | Â | Â | Â |
Linear trend treatment |  |  |  |  |  | P < 0.001 | P < 0.0001 | P < 0.0001 |  | ||
Invasive local recurrence | Â | Â | Â | Â | Â | Â | Â | Â | |||
Model P-value |  |  |  |  |  |  | P = 0.0005 | P < 0.0001 | P < 0.0001 |  | |
CS(alone) | 10 | 2038 | 241 | 11.4 | R | <0.05 | 60.1 | 11.2 | 11.3 | 2.61 | 0.001 |
 |  |  |  | 8.8–14.1 |  |  |  | 8.8–13.7 | 8.9–13.8 | 1.71–3.97 |  |
CS + TAM(no RT) | 1 | 567 | 49 | 8.6 | - | - | - | 8.6 | 11.0 | 2.52 | 0.001 |
 |  |  |  | 6.7–10.6 |  |  |  | 4.1–13.1 | 6.2–15.8 | 1.44–4.41 |  |
CS + RT(no TAM) | 8 | 4562 | 317 | 7.7 | R | <0.001 | 79.0 | 7.4 | 7.2 | 1.59 | 0.022 |
 |  |  |  | 5.9–9.5 |  |  |  | 5.8–8.9 | 6.1–8.3 | 1.07–2.35 |  |
CS + RT + TAM | 2 | 937 | 40 | 4.3 | F = R | ns | <0 | 4.1 | 4.7 | 1.00 |  |
 |  |  |  | 3.0–5.6 |  |  |  | 2.2–6.0 | 3.0–6.4 | - |  |
Total | 21 | 8104 | 647 | Â | Â | Â | Â | Â | Â | Â | Â |
Linear trend treatment |  |  |  |  |  | P < 0.0001 | P < 0.0001 | P < 0.0001 |  | ||
Breast cancer deaths | Â | Â | Â | Â | Â | Â | Â | Â | Â | ||
Model P-value |  |  |  |  |  |  | P = 0.6160 | P = 0.4152 | P = 0.4152 |  | |
CS(alone) | 8 | 1729 | 40 | 2.3 | F = R | ns | <0 | 2.1 | 2.1 | 1.15 | 0.734 |
 |  |  |  | 1.6-3.0 |  |  |  | 1.1–3.1 | 0.9–3.2 | 0.52–2.51 |  |
CS + TAM(no RT) | 1 | 567 | 19 | 3.4 | - | - | - | 3.3 | 4.0 | 2.24 | 0.128 |
 |  |  |  | 2.1–4.6 |  |  |  | 0.6–5.9 | 0.2–7.7 | 0.79–1.27 |  |
CS + RT(no TAM) | 8 | 2814 | 67 | 2.7 | R | <0.001 | 76.4 | 2.3 | 2.2 | 1.21 | 0.613 |
 |  |  |  | 1.4–3.9 |  |  |  | 1.5–3.2 | 1.2–3.1 | 0.58–2.54 |  |
CS + RT + TAM | 2 | 937 | 16 | 1.7 | R | ns | <0 | 1.6 | 1.8 | 1.00 |  |
 |  |  |  | 0.9–2.5 |  |  |  | 0.5–2.8 | 0.6–3.0 | - |  |
Total | 19 | 6047 | 142 | Â | Â | Â | Â | Â | Â | Â | Â |
Linear trend treatment |  |  |  |  |  | P = 0.8591 | P = 0.5586 | P = 0.5586 |  |