Fig. 3
From: Dual PI3K/mTOR inhibitor BEZ235 exerts extensive antitumor activity in HER2-positive gastric cancer
BEZ235 specifically targets HER2-postive gastric cancer cell lines. a The sensitivity of BEZ235 in NCI-N87 and SNU216 cells was significantly higher than that observed in MKN45 cells. b Western blotting analysis showed that the expression of p-AKT, p-ERK, and p-S6 in MKN45 cells was significantly lower than that observed in NCI-N87 cells. Proliferation assays are expressed as the Mean ± S.D of three replicate assays. Western blots were repeated twice. *P <0.01 according to factorial analysis. Cropped blots were used because the same experimental conditions were used for running all the gels