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Table 2 Genetic associations of rs3928672 with the lymph node metastasis of NPC

From: Argonaute 2 and nasopharyngeal carcinoma: a genetic association study and functional analysis

Populations

Genotypes

N classification, n (%)

OR (95 % CI)a

P valuea

  

N0

N1

N2

N3

  

Guangxi

 

(n = 177)

(n = 406)

(n = 180)

(n = 78)

  
 

GG

91 (51.4)

187 (46.1)

95 (52.8)

22 (28.2)

1.00 (reference)

 
 

GA

72 (40.7)

177 (43.6)

69 (38.3)

47 (60.3)

2.50 (1.47-4.25)

0.0010

 

AA

14 (7.9)

42 (10.3)

16 (8.9)

9 (11.5)

2.31 (1.01-5.27)

0.046

 

GA + AA

86 (48.6)

219 (53.9)

85 (47.2)

56 (71.8)

2.47 (1.47-4.13)

0.00030

Guangdong

 

(n = 226)

(n = 372)

(n = 260)

(n = 65)

  
 

GG

123 (54.4)

184 (49.5)

134 (51.5)

25 (38.5)

1.00 (reference)

 
 

GA

87 (38.5)

152 (40.8)

105 (40.4)

37 (56.9)

1.95 (1.14-3.34)

0.015

 

AA

16 (7.1)

36 (9.7)

21 (8.1)

3 (4.6)

0.79 (0.23-2.72)

0.71

 

GA + AA

103 (45.6)

188 (50.5)

126 (48.5)

40 (61.5)

1.75 (1.03-2.98)

0.034

Pooled

 

(n = 403)

(n = 778)

(n = 440)

(n = 143)

  
 

GG

214 (53.1)

371 (47.7)

229 (52.0)

47 (32.9)

1.00 (reference)

 
 

GA

159 (39.5)

329 (42.3)

174 (39.5)

84 (58.7)

2.22 (1.51-3.20)

4.07 × 10−5

 

AA

30 (7.4)

78 (10.0)

37 (8.5)

12 (8.4)

1.54 (0.79-2.99)

0.21

 

GA + AA

189 (46.9)

407 (52.3)

211 (48.0)

96 (67.1)

2.08 (1.44-3.01)

8.60 × 10−5

Overallb

 

(n = 403)

(n = 778)

(n = 440)

(n = 143)

  
 

GG

214 (53.1)

371 (47.7)

229 (52.0)

47 (32.9)

1.00 (reference)

 
 

GA

159 (39.5)

329 (42.3)

174 (39.5)

84 (58.7)

2.21 (1.52-3.23)

3.82 × 10−5

 

AA

30 (7.4)

78 (10.0)

37 (8.5)

12 (8.4)

1.66 (0.83-3.29)

0.15

 

GA + AA

189 (46.9)

407 (52.3)

211 (48.0)

96 (67.1)

2.09 (1.44-3.03)

9.64 × 10−5

  1. Note: Guangxi and Guangdong populations consist of 855 and 962 patients with known lymph node involvement (N classification) stage, respectively. Due to DNA quality and/or quantity, the actual sample sizes were 841 and 923 patients in the Guangxi and Guangdong population, respectively
  2. Abbreviations: N lymph node involvement, OR odds ratio, CI confidence interval
  3. aIn the Guangxi population, the ORs, 95 % CIs and P values were calculated for N3 vs. N0 + N1 + N2 and adjusted for sex, age, status of smoking and drinking, smoking level, family history and nationality. In the Guangdong population, the ORs, 95 % CIs and P values were calculated for N3 vs. N0 + N1 + N2 and adjusted for sex, age, status of smoking and drinking, and smoking level. In the pooled population, the ORs, 95 % CIs and P values were calculated for N3 vs. N0 + N1 + N2 and adjusted for sex, age, status of smoking and drinking, and smoking level. Another confounding factor, native place, was also adjusted in the pooled population
  4. bA meta-analysis combining two independent case–control studies. The P values for heterogeneity among sample sets are 0.52 for GA vs. GG group, 0.18 for AA vs. GG and 0.36 for GA + AA vs. GG group, respectively
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BMC Cancer

ISSN: 1471-2407

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