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Table 2 Genetic associations of rs3928672 with the lymph node metastasis of NPC

From: Argonaute 2 and nasopharyngeal carcinoma: a genetic association study and functional analysis

Populations Genotypes N classification, n (%) OR (95 % CI)a P valuea
   N0 N1 N2 N3   
Guangxi   (n = 177) (n = 406) (n = 180) (n = 78)   
  GG 91 (51.4) 187 (46.1) 95 (52.8) 22 (28.2) 1.00 (reference)  
  GA 72 (40.7) 177 (43.6) 69 (38.3) 47 (60.3) 2.50 (1.47-4.25) 0.0010
  AA 14 (7.9) 42 (10.3) 16 (8.9) 9 (11.5) 2.31 (1.01-5.27) 0.046
  GA + AA 86 (48.6) 219 (53.9) 85 (47.2) 56 (71.8) 2.47 (1.47-4.13) 0.00030
Guangdong   (n = 226) (n = 372) (n = 260) (n = 65)   
  GG 123 (54.4) 184 (49.5) 134 (51.5) 25 (38.5) 1.00 (reference)  
  GA 87 (38.5) 152 (40.8) 105 (40.4) 37 (56.9) 1.95 (1.14-3.34) 0.015
  AA 16 (7.1) 36 (9.7) 21 (8.1) 3 (4.6) 0.79 (0.23-2.72) 0.71
  GA + AA 103 (45.6) 188 (50.5) 126 (48.5) 40 (61.5) 1.75 (1.03-2.98) 0.034
Pooled   (n = 403) (n = 778) (n = 440) (n = 143)   
  GG 214 (53.1) 371 (47.7) 229 (52.0) 47 (32.9) 1.00 (reference)  
  GA 159 (39.5) 329 (42.3) 174 (39.5) 84 (58.7) 2.22 (1.51-3.20) 4.07 × 10−5
  AA 30 (7.4) 78 (10.0) 37 (8.5) 12 (8.4) 1.54 (0.79-2.99) 0.21
  GA + AA 189 (46.9) 407 (52.3) 211 (48.0) 96 (67.1) 2.08 (1.44-3.01) 8.60 × 10−5
Overallb   (n = 403) (n = 778) (n = 440) (n = 143)   
  GG 214 (53.1) 371 (47.7) 229 (52.0) 47 (32.9) 1.00 (reference)  
  GA 159 (39.5) 329 (42.3) 174 (39.5) 84 (58.7) 2.21 (1.52-3.23) 3.82 × 10−5
  AA 30 (7.4) 78 (10.0) 37 (8.5) 12 (8.4) 1.66 (0.83-3.29) 0.15
  GA + AA 189 (46.9) 407 (52.3) 211 (48.0) 96 (67.1) 2.09 (1.44-3.03) 9.64 × 10−5
  1. Note: Guangxi and Guangdong populations consist of 855 and 962 patients with known lymph node involvement (N classification) stage, respectively. Due to DNA quality and/or quantity, the actual sample sizes were 841 and 923 patients in the Guangxi and Guangdong population, respectively
  2. Abbreviations: N lymph node involvement, OR odds ratio, CI confidence interval
  3. aIn the Guangxi population, the ORs, 95 % CIs and P values were calculated for N3 vs. N0 + N1 + N2 and adjusted for sex, age, status of smoking and drinking, smoking level, family history and nationality. In the Guangdong population, the ORs, 95 % CIs and P values were calculated for N3 vs. N0 + N1 + N2 and adjusted for sex, age, status of smoking and drinking, and smoking level. In the pooled population, the ORs, 95 % CIs and P values were calculated for N3 vs. N0 + N1 + N2 and adjusted for sex, age, status of smoking and drinking, and smoking level. Another confounding factor, native place, was also adjusted in the pooled population
  4. bA meta-analysis combining two independent case–control studies. The P values for heterogeneity among sample sets are 0.52 for GA vs. GG group, 0.18 for AA vs. GG and 0.36 for GA + AA vs. GG group, respectively