Argonaute 2 and nasopharyngeal carcinoma: a genetic association study and functional analysis

BMC Cancer

Table 1 Positions and frequencies of SNPs within AGO2 gene

No.	SNPs^a	Alleles (Minor/Major)	Frequencies^b	Positions^c	Regions
1	rs4961280	C/A	0.111	−1809	Promoter
2	rs11996715	C/A	0.430	−1686	Promoter
3	rs4961226	G/T	0.400	3050	Intron 1
4	rs10088596	C/T	0.453	5311	Intron 1
5	rs883596	G/C	0.105	9957	Intron 1
6	rs13261055	A/G	0.386	16208	Intron 1
7	rs7001653	G/A	0.444	24567	Intron 1
8	rs7819727	A/G	0.452	48394	Intron 1
9	rs7009635	T/C	0.367	50724	Intron 2
10	rs7005286	C/T	0.337	51145	Intron 2
11	rs11776034	C/G	0.211	53712	Intron 2
12	rs3735805	C/T	0.356	68083	Intron 3
13	rs2977490	A/G	0.453	72247	Intron 3
14	rs2292773	C/T	0.278	73107	Intron 4
15	rs3928672	G/A	0.222	73438	Intron 4
16	rs2271735	G/T	0.178	76295	Intron 6
17	rs2977481	G/C	0.183	83748	Intron 10
18	rs2292779	G/C	0.244	84394	Intron 11
19	rs2944764	C/T	0.239	84576	Intron 11
20	rs11166983	G/A	0.278	87519	Intron 11
21	rs12542354	C/T	0.239	89462	Intron 13
22	rs13252337	A/G	0.186	96222	Intron 16
23	rs2977469	G/A	0.465	96314	Intron 16
24	rs2977464	C/T	0.333	100412	Intron 16
25	rs2977462	T/C	0.467	102467	Intron 16

SNPs in bold were not in Hardy-Weinberg equilibrium (HWE) (rs883596 and rs2977490, both P < 0.05) or failed genotyping (rs2977481) in the Guangxi population
^adbSNP ID number
^bMinor allele frequencies in HapMap-HCB (HCB, unrelated Han Chinese in Beijing, China)
^cThe position of the SNPs is relative to the first nucleotide of the open reading frame of the AGO2 gene, referred to as accession number NT_008046.15

ISSN: 1471-2407