Fig. 6
From: Primary myeloma interaction and growth in coculture with healthy donor hematopoietic bone marrow
The NBM coculture system provides a platform to test MM cell response to clinical agents. Bioluminescence analysis of luciferase-expressing OPM2 (a), ARP1 (b) and patient MM cells (c; maintained by passaging through SCID-rab mice; Pt#15) cocultured in the NBM system (black bars) or cultured alone in their standard conditions (gray bars) and exposed to indicated concentrations of dexamethasone, bortezomib and lenalidomide. Data are represented as percent growth inhibition relative to the respective untreated MM cells (CONT; set to 100Â %)